Expression of ABCB9 in cancer - Summary

CANCER ATLAS

Gene description

ATP-binding cassette, sub-family B (MDR/TAP), member 9

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA035114	CAB033052

GENE INFORMATION
Gene name	ABCB9 (HGNC Symbol)
Synonyms	EST122234
Description	ATP-binding cassette, sub-family B (MDR/TAP), member 9 (HGNC Symbol)
Entrez gene summary	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This family member functions in the translocation of peptides from the cytosol into the lysosomal lumen. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specificities. [provided by RefSeq, Jul 2011]
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	122920951 - 122981649
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000150967 (version 83.38)
Entrez gene	23457
UniProt	Q9NP78 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NP78
Antibodypedia	ABCB9 antibodies

PROTEIN BROWSER

ABCB9-001	ABCB9-002	ABCB9-003	ABCB9-004	ABCB9-005	ABCB9-006	ABCB9-011	ABCB9-012	ABCB9-013	ABCB9-014	ABCB9-015	ABCB9-016	ABCB9-018	ABCB9-019	ABCB9-201	ABCB9-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCB9-001 ENSP00000440288 ENST00000542678	Q9NP78 [Direct mapping] ATP-binding cassette sub-family B member 9 A0A024RBU1 [Target identity:100%; Query identity:100%] ATP-binding cassette, sub-family B (MDR/TAP), member 9, isoform CRA_f Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0015031 [protein transport] GO:0015421 [oligopeptide-transporting ATPase activity] GO:0015440 [peptide-transporting ATPase activity] GO:0015833 [peptide transport] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0035672 [oligopeptide transmembrane transport] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042803 [protein homodimerization activity] GO:0055085 [transmembrane transport] Show all	766 aa 84.5 kDa	No	8
ABCB9-002 ENSP00000376234 ENST00000392439	Q9NP78 [Direct mapping] ATP-binding cassette sub-family B member 9 A0A024RBU1 [Target identity:100%; Query identity:100%] ATP-binding cassette, sub-family B (MDR/TAP), member 9, isoform CRA_f Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0015031 [protein transport] GO:0015421 [oligopeptide-transporting ATPase activity] GO:0015440 [peptide-transporting ATPase activity] GO:0015833 [peptide transport] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0035672 [oligopeptide transmembrane transport] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042803 [protein homodimerization activity] GO:0055085 [transmembrane transport] Show all	766 aa 84.5 kDa	No	8
ABCB9-003 ENSP00000441734 ENST00000540285	Q9NP78 [Direct mapping] ATP-binding cassette sub-family B member 9 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0015031 [protein transport] GO:0015421 [oligopeptide-transporting ATPase activity] GO:0015440 [peptide-transporting ATPase activity] GO:0015833 [peptide transport] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0035672 [oligopeptide transmembrane transport] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042803 [protein homodimerization activity] GO:0055085 [transmembrane transport] Show all	703 aa 77.5 kDa	No	7
ABCB9-004 ENSP00000280560 ENST00000280560	Q9NP78 [Direct mapping] ATP-binding cassette sub-family B member 9 A0A024RBU1 [Target identity:100%; Query identity:100%] ATP-binding cassette, sub-family B (MDR/TAP), member 9, isoform CRA_f Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0015031 [protein transport] GO:0015421 [oligopeptide-transporting ATPase activity] GO:0015440 [peptide-transporting ATPase activity] GO:0015833 [peptide transport] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0035672 [oligopeptide transmembrane transport] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042803 [protein homodimerization activity] GO:0055085 [transmembrane transport] Show all	766 aa 84.5 kDa	No	8
ABCB9-005 ENSP00000456375 ENST00000442833	Q9NP78 [Direct mapping] ATP-binding cassette sub-family B member 9 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0015031 [protein transport] GO:0015421 [oligopeptide-transporting ATPase activity] GO:0015440 [peptide-transporting ATPase activity] GO:0015833 [peptide transport] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0035672 [oligopeptide transmembrane transport] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042803 [protein homodimerization activity] GO:0055085 [transmembrane transport] Show all	683 aa 75.4 kDa	No	8
ABCB9-006 ENSP00000456813 ENST00000344275	Q9NP78 [Direct mapping] ATP-binding cassette sub-family B member 9 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0015031 [protein transport] GO:0015421 [oligopeptide-transporting ATPase activity] GO:0015440 [peptide-transporting ATPase activity] GO:0015833 [peptide transport] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0035672 [oligopeptide transmembrane transport] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042803 [protein homodimerization activity] GO:0055085 [transmembrane transport] Show all	681 aa 75.3 kDa	No	8
ABCB9-011 ENSP00000443382 ENST00000543935	F5H5I5 [Direct mapping] ATP-binding cassette sub-family B member 9 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	65 aa 7.4 kDa	No	1
ABCB9-012 ENSP00000441086 ENST00000540971	F5GX86 [Direct mapping] ATP-binding cassette sub-family B member 9 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005524 [ATP binding] GO:0006810 [transport] GO:0016021 [integral component of membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	182 aa 20.3 kDa	No	3
ABCB9-013 ENSP00000440138 ENST00000541424	F5GXZ5 [Direct mapping] ATP-binding cassette sub-family B member 9 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005524 [ATP binding] GO:0006810 [transport] GO:0016021 [integral component of membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	146 aa 16.3 kDa	No	2
ABCB9-014 ENSP00000443433 ENST00000536976	F5H5F9 [Direct mapping] ATP-binding cassette sub-family B member 9 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005524 [ATP binding] GO:0006810 [transport] GO:0016021 [integral component of membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	222 aa 25.2 kDa	No	4
ABCB9-015 ENSP00000443224 ENST00000546077	F5H5Q0 [Direct mapping] ATP-binding cassette sub-family B member 9 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005524 [ATP binding] GO:0006810 [transport] GO:0016021 [integral component of membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	115 aa 13 kDa	No	1
ABCB9-016 ENSP00000440244 ENST00000542448	F5GYI2 [Direct mapping] ATP-binding cassette sub-family B member 9 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005524 [ATP binding] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	260 aa 28.8 kDa	No	2
ABCB9-018 ENSP00000442281 ENST00000546289	F5H7U2 [Direct mapping] ATP-binding cassette sub-family B member 9 Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005524 [ATP binding] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	277 aa 29.8 kDa	No	0
ABCB9-019 ENSP00000444834 ENST00000545373	F5H4Y2 [Direct mapping] ATP-binding cassette sub-family B member 9 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005524 [ATP binding] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	156 aa 16.7 kDa	No	2
ABCB9-201 ENSP00000280559 ENST00000346530	Q9NP78 [Direct mapping] ATP-binding cassette sub-family B member 9 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0015031 [protein transport] GO:0015421 [oligopeptide-transporting ATPase activity] GO:0015440 [peptide-transporting ATPase activity] GO:0015833 [peptide transport] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0035672 [oligopeptide transmembrane transport] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042803 [protein homodimerization activity] GO:0055085 [transmembrane transport] Show all	723 aa 79.8 kDa	No	7
ABCB9-202 ENSP00000394898 ENST00000442028	Q6P2Q0 [Direct mapping] ABCB9 protein; ATP-binding cassette sub-family B member 9 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0005524 [ATP binding] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	769 aa 84.8 kDa	No	8