Expression of DCP1B in cancer - Summary

CANCER ATLAS

Gene description

Decapping mRNA 1B

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA039709

GENE INFORMATION
Gene name	DCP1B (HGNC Symbol)
Synonyms	FLJ31638
Description	Decapping mRNA 1B (HGNC Symbol)
Entrez gene summary	DCP1B is a core component of the mRNA decapping complex, a key factor in the regulation of mRNA decay (Lykke-Andersen, 2002 [PubMed 12417715]).[supplied by OMIM, Mar 2008]
Chromosome	12
Cytoband	p13.33
Chromosome location (bp)	1946054 - 2004535
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151065 (version 83.38)
Entrez gene	196513
UniProt	Q8IZD4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IZD4
Antibodypedia	DCP1B antibodies

PROTEIN BROWSER

DCP1B-001	DCP1B-002	DCP1B-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DCP1B-001 ENSP00000482714 ENST00000535873	B4DVJ6 [Direct mapping] cDNA FLJ57612, highly similar to mRNA decapping enzyme 1B (EC 3.-.-.-); mRNA-decapping enzyme 1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000290 [deadenylation-dependent decapping of nuclear-transcribed mRNA] GO:0000932 [cytoplasmic mRNA processing body] GO:0003729 [mRNA binding] GO:0030234 [enzyme regulator activity] GO:0031087 [deadenylation-independent decapping of nuclear-transcribed mRNA] GO:0050790 [regulation of catalytic activity] Show all	153 aa 17.1 kDa	No	1
DCP1B-002 ENSP00000280665 ENST00000280665	Q8IZD4 [Direct mapping] mRNA-decapping enzyme 1B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000290 [deadenylation-dependent decapping of nuclear-transcribed mRNA] GO:0000932 [cytoplasmic mRNA processing body] GO:0003729 [mRNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0030234 [enzyme regulator activity] GO:0031087 [deadenylation-independent decapping of nuclear-transcribed mRNA] GO:0043231 [intracellular membrane-bounded organelle] GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay] GO:0050790 [regulation of catalytic activity] Show all	617 aa 67.7 kDa	No	0
DCP1B-007 ENSP00000444374 ENST00000540622	F5GZK9 [Direct mapping] mRNA-decapping enzyme 1B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000290 [deadenylation-dependent decapping of nuclear-transcribed mRNA] GO:0000932 [cytoplasmic mRNA processing body] GO:0003729 [mRNA binding] GO:0005737 [cytoplasm] GO:0030234 [enzyme regulator activity] GO:0031087 [deadenylation-independent decapping of nuclear-transcribed mRNA] GO:0043231 [intracellular membrane-bounded organelle] GO:0050790 [regulation of catalytic activity] Show all	390 aa 42.5 kDa	No	0