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DCP1B

GENERAL INFORMATION

Gene name

 DCP1B

Gene description

 Decapping mRNA 1B

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA039709
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DCP1B (HGNC Symbol)

Synonyms

 FLJ31638

Description

 Decapping mRNA 1B (HGNC Symbol)

Entrez gene summary

 DCP1B is a core component of the mRNA decapping complex, a key factor in the regulation of mRNA decay (Lykke-Andersen, 2002 [PubMed 12417715]).[supplied by OMIM, Mar 2008]

Chromosome

 12

Cytoband

 p13.33

Chromosome location (bp)

 1946054 - 2004535

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151065 (version 83.38)

Entrez gene

 196513

UniProt

 Q8IZD4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IZD4

Antibodypedia

 DCP1B antibodies

PROTEIN BROWSER
DCP1B-001
DCP1B-002
DCP1B-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DCP1B-001
ENSP00000482714
ENST00000535873
B4DVJ6 [Direct mapping]
cDNA FLJ57612, highly similar to mRNA decapping enzyme 1B (EC 3.-.-.-); mRNA-decapping enzyme 1B
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000290 [deadenylation-dependent decapping of nuclear-transcribed mRNA]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003729 [mRNA binding]
GO:0030234 [enzyme regulator activity]
GO:0031087 [deadenylation-independent decapping of nuclear-transcribed mRNA]
GO:0050790 [regulation of catalytic activity]
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 153 aa
17.1 kDa 		No 1
DCP1B-002
ENSP00000280665
ENST00000280665
Q8IZD4 [Direct mapping]
mRNA-decapping enzyme 1B
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000290 [deadenylation-dependent decapping of nuclear-transcribed mRNA]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0030234 [enzyme regulator activity]
GO:0031087 [deadenylation-independent decapping of nuclear-transcribed mRNA]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0050790 [regulation of catalytic activity]
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 617 aa
67.7 kDa 		No 0
DCP1B-007
ENSP00000444374
ENST00000540622
F5GZK9 [Direct mapping]
mRNA-decapping enzyme 1B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000290 [deadenylation-dependent decapping of nuclear-transcribed mRNA]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003729 [mRNA binding]
GO:0005737 [cytoplasm]
GO:0030234 [enzyme regulator activity]
GO:0031087 [deadenylation-independent decapping of nuclear-transcribed mRNA]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0050790 [regulation of catalytic activity]
Show all
 390 aa
42.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.