Expression of NEK7 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

NIMA-related kinase 7

Protein class

Enzymes, Predicted intracellular proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA015520	HPA018193

GENE INFORMATION
Gene name	NEK7
Synonyms
Description	NIMA-related kinase 7 (HGNC Symbol)
Entrez gene summary	NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]
Chromosome	1
Cytoband	q31.3
Chromosome location (bp)	198156963 - 198322420
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151414 (version 83.38)
Entrez gene	140609
UniProt	Q8TDX7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TDX7
Antibodypedia	NEK7 antibodies

PROTEIN BROWSER

NEK7-001	NEK7-003	NEK7-005	NEK7-006	NEK7-007	NEK7-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NEK7-001 ENSP00000356355 ENST00000367385	Q8TDX7 [Direct mapping] Serine/threonine-protein kinase Nek7 A0A024R964 [Target identity:100%; Query identity:100%] NIMA (Never in mitosis gene a)-related kinase 7, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases NEK Ser/Thr protein kinases Transporters Transporter channels and pores MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000910 [cytokinesis] GO:0000922 [spindle pole] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0046872 [metal ion binding] GO:0051225 [spindle assembly] Show all	302 aa 34.6 kDa	No	0
NEK7-003 ENSP00000356353 ENST00000367383	Q8TDX7 [Direct mapping] Serine/threonine-protein kinase Nek7 Show all	Enzymes ENZYME proteins Transferases Kinases NEK Ser/Thr protein kinases Transporters Transporter channels and pores Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000910 [cytokinesis] GO:0000922 [spindle pole] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0046872 [metal ion binding] GO:0051225 [spindle assembly] Show all	119 aa 13.4 kDa	No	0
NEK7-005 ENSP00000392745 ENST00000442588	C9J1H8 [Direct mapping] Serine/threonine-protein kinase Nek7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0006468 [protein phosphorylation] Show all	32 aa 3.6 kDa	No	0
NEK7-006 ENSP00000444621 ENST00000538004	Q8TDX7 [Direct mapping] Serine/threonine-protein kinase Nek7 A0A024R964 [Target identity:100%; Query identity:100%] NIMA (Never in mitosis gene a)-related kinase 7, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases NEK Ser/Thr protein kinases Transporters Transporter channels and pores MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000910 [cytokinesis] GO:0000922 [spindle pole] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0046872 [metal ion binding] GO:0051225 [spindle assembly] Show all	302 aa 34.6 kDa	No	0
NEK7-007 ENSP00000439095 ENST00000544035	F5H3U7 [Direct mapping] Serine/threonine-protein kinase Nek7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0006468 [protein phosphorylation] Show all	62 aa 6.9 kDa	No	0
NEK7-008 ENSP00000375835 ENST00000391974	F8WAG2 [Direct mapping] Serine/threonine-protein kinase Nek7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	82 aa 9.2 kDa	No	0