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NEK7

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GENERAL INFORMATION

Gene name

 NEK7

Gene description

 NIMA-related kinase 7

Protein class

 Enzymes
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA018193
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA018193 A-431 Nucleoplasm
HPA018193 U-251 MG Nucleoplasm Intensity

GENE INFORMATION

Gene name

 NEK7

Synonyms

Description

 NIMA-related kinase 7 (HGNC Symbol)

Entrez gene summary

 NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]

Chromosome

 1

Cytoband

 q31.3

Chromosome location (bp)

 198156963 - 198322420

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151414 (version 83.38)

Entrez gene

 140609

UniProt

 Q8TDX7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TDX7

Antibodypedia

 NEK7 antibodies

PROTEIN BROWSER
NEK7-001
NEK7-003
NEK7-005
NEK7-006
NEK7-007
NEK7-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NEK7-001
ENSP00000356355
ENST00000367385
Q8TDX7 [Direct mapping]
Serine/threonine-protein kinase Nek7
A0A024R964 [Target identity:100%; Query identity:100%]
NIMA (Never in mitosis gene a)-related kinase 7, isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
Transporters
   Transporter channels and pores
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0000922 [spindle pole]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005874 [microtubule]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0046872 [metal ion binding]
GO:0051225 [spindle assembly]
Show all
 302 aa
34.6 kDa 		No 0
NEK7-003
ENSP00000356353
ENST00000367383
Q8TDX7 [Direct mapping]
Serine/threonine-protein kinase Nek7
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0000922 [spindle pole]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005874 [microtubule]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0046872 [metal ion binding]
GO:0051225 [spindle assembly]
Show all
 119 aa
13.4 kDa 		No 0
NEK7-005
ENSP00000392745
ENST00000442588
C9J1H8 [Direct mapping]
Serine/threonine-protein kinase Nek7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0006468 [protein phosphorylation]
Show all
 32 aa
3.6 kDa 		No 0
NEK7-006
ENSP00000444621
ENST00000538004
Q8TDX7 [Direct mapping]
Serine/threonine-protein kinase Nek7
A0A024R964 [Target identity:100%; Query identity:100%]
NIMA (Never in mitosis gene a)-related kinase 7, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
Transporters
   Transporter channels and pores
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0000922 [spindle pole]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005874 [microtubule]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0046872 [metal ion binding]
GO:0051225 [spindle assembly]
Show all
 302 aa
34.6 kDa 		No 0
NEK7-007
ENSP00000439095
ENST00000544035
F5H3U7 [Direct mapping]
Serine/threonine-protein kinase Nek7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0006468 [protein phosphorylation]
Show all
 62 aa
6.9 kDa 		No 0
NEK7-008
ENSP00000375835
ENST00000391974
F8WAG2 [Direct mapping]
Serine/threonine-protein kinase Nek7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 82 aa
9.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.