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FER

CANCER ATLAS

Gene description

 Fer (fps/fes related) tyrosine kinase

Protein class

 Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA007641
CAB022464

GENE INFORMATION

Gene name

 FER (HGNC Symbol)

Synonyms

 PPP1R74, TYK3

Description

 Fer (fps/fes related) tyrosine kinase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the FPS/FES family of non-transmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Apr 2015]

Chromosome

 5

Cytoband

 q21.3

Chromosome location (bp)

 108747822 - 109196841

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151422 (version 83.38)

Entrez gene

 2241

UniProt

 P16591 (UniProt - Evidence at protein level)

neXtProt

 NX_P16591

Antibodypedia

 FER antibodies

PROTEIN BROWSER
FER-001
FER-201
FER-202
FER-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FER-001
ENSP00000281092
ENST00000281092
P16591 [Direct mapping]
Tyrosine-protein kinase Fer
W0S0X4 [Target identity:100%; Query identity:100%]
Tyrosine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0000790 [nuclear chromatin]
GO:0001932 [regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006935 [chemotaxis]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0008157 [protein phosphatase 1 binding]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0010591 [regulation of lamellipodium assembly]
GO:0010762 [regulation of fibroblast migration]
GO:0015629 [actin cytoskeleton]
GO:0015630 [microtubule cytoskeleton]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030154 [cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032496 [response to lipopolysaccharide]
GO:0032869 [cellular response to insulin stimulus]
GO:0033007 [negative regulation of mast cell activation involved in immune response]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035426 [extracellular matrix-cell signaling]
GO:0035556 [intracellular signal transduction]
GO:0036006 [cellular response to macrophage colony-stimulating factor stimulus]
GO:0036119 [response to platelet-derived growth factor]
GO:0038028 [insulin receptor signaling pathway via phosphatidylinositol 3-kinase]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038109 [Kit signaling pathway]
GO:0042058 [regulation of epidermal growth factor receptor signaling pathway]
GO:0042503 [tyrosine phosphorylation of Stat3 protein]
GO:0043304 [regulation of mast cell degranulation]
GO:0044331 [cell-cell adhesion mediated by cadherin]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0050904 [diapedesis]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0070102 [interleukin-6-mediated signaling pathway]
Show all
 822 aa
94.6 kDa 		No 0
FER-201
ENSP00000394297
ENST00000438717
W0S4B9 [Direct mapping]
Non-specific protein-tyrosine kinase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0006935 [chemotaxis]
GO:0007155 [cell adhesion]
GO:0008283 [cell proliferation]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031532 [actin cytoskeleton reorganization]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042058 [regulation of epidermal growth factor receptor signaling pathway]
GO:0043304 [regulation of mast cell degranulation]
GO:0045087 [innate immune response]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
 411 aa
47 kDa 		No 0
FER-202
ENSP00000484767
ENST00000618353
P16591 [Direct mapping]
Tyrosine-protein kinase Fer
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0000790 [nuclear chromatin]
GO:0001932 [regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006935 [chemotaxis]
GO:0007155 [cell adhesion]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0010591 [regulation of lamellipodium assembly]
GO:0015629 [actin cytoskeleton]
GO:0015630 [microtubule cytoskeleton]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030154 [cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032496 [response to lipopolysaccharide]
GO:0032869 [cellular response to insulin stimulus]
GO:0033007 [negative regulation of mast cell activation involved in immune response]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035426 [extracellular matrix-cell signaling]
GO:0035556 [intracellular signal transduction]
GO:0036006 [cellular response to macrophage colony-stimulating factor stimulus]
GO:0036119 [response to platelet-derived growth factor]
GO:0038028 [insulin receptor signaling pathway via phosphatidylinositol 3-kinase]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038109 [Kit signaling pathway]
GO:0042058 [regulation of epidermal growth factor receptor signaling pathway]
GO:0042503 [tyrosine phosphorylation of Stat3 protein]
GO:0043304 [regulation of mast cell degranulation]
GO:0044331 [cell-cell adhesion mediated by cadherin]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0050904 [diapedesis]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0070102 [interleukin-6-mediated signaling pathway]
Show all
 453 aa
51.6 kDa 		No 0
FER-203
ENSP00000486048
ENST00000628534
A0A0D9SEV4 [Direct mapping]
Tyrosine-protein kinase Fer
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004713 [protein tyrosine kinase activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0006935 [chemotaxis]
GO:0007155 [cell adhesion]
GO:0008283 [cell proliferation]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031532 [actin cytoskeleton reorganization]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042058 [regulation of epidermal growth factor receptor signaling pathway]
GO:0043304 [regulation of mast cell degranulation]
GO:0045087 [innate immune response]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
 163 aa
19 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.