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Gene name

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Chromosome

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In atlas

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Reliability

Reliability

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Validation

Method

Validation

Method

Validation

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Searches

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Expression

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Specificity

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Detectable

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AKR1C2
  • TISSUE

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

AKR1C2

Gene description

Aldo-keto reductase family 1, member C2

Protein class

Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (adipose tissue, gallbladder, liver, urinary bladder, stomach, breast, esophagus)
GTEx:Mixed
FANTOM5:Tissue enhanced (liver, adipose tissue, breast)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues, most prominent in urinary bladder, intestinal tract and liver.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
CAB047304
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
N/A
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adipose tissue, gallbladder, liver, urinary bladder, stomach, breast, esophagus)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver, adipose tissue, breast)

GENE INFORMATION

Gene name

AKR1C2 (HGNC Symbol)

Synonyms

BABP, DD, DD2, DDH2, HAKRD, MCDR2, TDD

Description

Aldo-keto reductase family 1, member C2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Chromosome

10

Cytoband

p15.1

Chromosome location (bp)

4922564 - 5135226

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000151632 (version 83.38)

Entrez gene

1646

UniProt

P52895 (UniProt - Evidence at protein level)

neXtProt

NX_P52895

Antibodypedia

AKR1C2 antibodies

PROTEIN BROWSER

AKR1C2-001
AKR1C2-003
AKR1C2-007
AKR1C2-201
AKR1C2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AKR1C2-001
ENSP00000370129
ENST00000380753
P52895 [Direct mapping]
Aldo-keto reductase family 1 member C2
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004032 [alditol:NADP+ 1-oxidoreductase activity]
GO:0005737 [cytoplasm]
GO:0006693 [prostaglandin metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007586 [digestion]
GO:0008202 [steroid metabolic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0016491 [oxidoreductase activity]
GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor]
GO:0018636 [phenanthrene 9,10-monooxygenase activity]
GO:0030855 [epithelial cell differentiation]
GO:0031406 [carboxylic acid binding]
GO:0032052 [bile acid binding]
GO:0042448 [progesterone metabolic process]
GO:0044597 [daunorubicin metabolic process]
GO:0044598 [doxorubicin metabolic process]
GO:0047086 [ketosteroid monooxygenase activity]
GO:0047115 [trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0055114 [oxidation-reduction process]
GO:0071395 [cellular response to jasmonic acid stimulus]
GO:0071799 [cellular response to prostaglandin D stimulus]
Show all
323 aa
36.7 kDa
No 0
AKR1C2-003
ENSP00000392694
ENST00000421196
B4DK69 [Direct mapping]
Aldo-keto reductase family 1 member C2; cDNA FLJ52680, highly similar to Aldo-keto reductase family 1 member C2 (EC 1.-.-.-)
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
297 aa
33.8 kDa
No 0
AKR1C2-007
ENSP00000474566
ENST00000604507
S4R3P0 [Direct mapping]
Aldo-keto reductase family 1 member C2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
200 aa
22.6 kDa
No 0
AKR1C2-201
ENSP00000385221
ENST00000407674
A0A0A0MSD5 [Direct mapping]
Aldo-keto reductase family 1 member C2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
323 aa
36.8 kDa
No 0
AKR1C2-202
ENSP00000408440
ENST00000455190
P52895 [Direct mapping]
Aldo-keto reductase family 1 member C2
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004032 [alditol:NADP+ 1-oxidoreductase activity]
GO:0005737 [cytoplasm]
GO:0006693 [prostaglandin metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007586 [digestion]
GO:0008202 [steroid metabolic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor]
GO:0018636 [phenanthrene 9,10-monooxygenase activity]
GO:0030855 [epithelial cell differentiation]
GO:0031406 [carboxylic acid binding]
GO:0032052 [bile acid binding]
GO:0042448 [progesterone metabolic process]
GO:0044597 [daunorubicin metabolic process]
GO:0044598 [doxorubicin metabolic process]
GO:0047086 [ketosteroid monooxygenase activity]
GO:0047115 [trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0055114 [oxidation-reduction process]
GO:0071395 [cellular response to jasmonic acid stimulus]
GO:0071799 [cellular response to prostaglandin D stimulus]
Show all
139 aa
15.7 kDa
No 0

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