Expression of BAG3 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

BCL2-associated athanogene 3

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA018493	HPA020586

GENE INFORMATION
Gene name	BAG3
Synonyms
Description	BCL2-associated athanogene 3 (HGNC Symbol)
Entrez gene summary	BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q26.11
Chromosome location (bp)	119651370 - 119677819
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151929 (version 83.38)
Entrez gene	9531
UniProt	O95817 (UniProt - Evidence at protein level)
neXtProt	NX_O95817
Antibodypedia	BAG3 antibodies

PROTEIN BROWSER

BAG3-001	BAG3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BAG3-001 ENSP00000358081 ENST00000369085	O95817 [Direct mapping] BAG family molecular chaperone regulator 3 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006457 [protein folding] GO:0007420 [brain development] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0010664 [negative regulation of striated muscle cell apoptotic process] GO:0021510 [spinal cord development] GO:0030018 [Z disc] GO:0032403 [protein complex binding] GO:0034605 [cellular response to heat] GO:0043005 [neuron projection] GO:0043066 [negative regulation of apoptotic process] GO:0050821 [protein stabilization] GO:0051087 [chaperone binding] GO:0071260 [cellular response to mechanical stimulus] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:1900034 [regulation of cellular response to heat] Show all	575 aa 61.6 kDa	No	0
BAG3-002 ENSP00000410036 ENST00000450186	C9JFK9 [Direct mapping] BAG family molecular chaperone regulator 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] Show all	325 aa 34.8 kDa	No	0