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POU4F1

GENERAL INFORMATION

Gene name

 POU4F1

Gene description

 POU class 4 homeobox 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Group enriched (retina, testis, appendix, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in retina.

DATA RELIABILITY

Data reliability
description

 External characterization data supports antibody staining but no internal RNA data available for correlation.

Reliability score

 Supported based on 1 antibody.
HPA068024
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Eye
N/A
Retina
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Retina

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (retina, testis, appendix, tonsil)

GENE INFORMATION

Gene name

 POU4F1 (HGNC Symbol)

Synonyms

 BRN3A, RDC-1

Description

 POU class 4 homeobox 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias. [provided by RefSeq, Mar 2012]

Chromosome

 13

Cytoband

 q31.1

Chromosome location (bp)

 78598362 - 78603560

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152192 (version 83.38)

Entrez gene

 5457

UniProt

 Q01851 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q01851

Antibodypedia

 POU4F1 antibodies

PROTEIN BROWSER
POU4F1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POU4F1-001
ENSP00000366413
ENST00000377208
Q01851 [Direct mapping]
POU domain, class 4, transcription factor 1
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0001967 [suckling behavior]
GO:0003223 [ventricular compact myocardium morphogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007399 [nervous system development]
GO:0007409 [axonogenesis]
GO:0007416 [synapse assembly]
GO:0007498 [mesoderm development]
GO:0021535 [cell migration in hindbrain]
GO:0021559 [trigeminal nerve development]
GO:0021953 [central nervous system neuron differentiation]
GO:0021986 [habenula development]
GO:0030182 [neuron differentiation]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048665 [neuron fate specification]
GO:0048880 [sensory system development]
GO:0048934 [peripheral nervous system neuron differentiation]
GO:0048935 [peripheral nervous system neuron development]
GO:0050767 [regulation of neurogenesis]
GO:0051355 [proprioception involved in equilibrioception]
GO:0060384 [innervation]
GO:0071158 [positive regulation of cell cycle arrest]
GO:2001208 [negative regulation of transcription elongation from RNA polymerase I promoter]
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 419 aa
42.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.