Cell atlas - EPG5 - The Human Protein Atlas

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EPG5

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	EPG5
Gene description	Ectopic P-granules autophagy protein 5 homolog (C. elegans)
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear speckles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA031689
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear speckles.

Main location

Nuclear speckles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA031689	A-431	Nuclear speckles
	HPA031689	U-2 OS	Nuclear speckles
	HPA031689	U-251 MG	Nuclear speckles

GENE INFORMATION
Gene name	EPG5 (HGNC Symbol)
Synonyms	hEPG5, KIAA1632
Description	Ectopic P-granules autophagy protein 5 homolog (C. elegans) (HGNC Symbol)
Entrez gene summary	This gene encodes a large coiled coil domain-containing protein that functions in autophagy during starvation conditions. Mutations in this gene cause Vici syndrome. [provided by RefSeq, Aug 2015]
Chromosome	18
Cytoband
Chromosome location (bp)	45847609 - 45967274
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152223 (version 83.38)
Entrez gene	57724
UniProt	Q9HCE0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9HCE0
Antibodypedia	EPG5 antibodies

PROTEIN BROWSER

EPG5-001	EPG5-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EPG5-001 ENSP00000282041 ENST00000282041	Q9HCE0 [Direct mapping] Ectopic P granules protein 5 homolog Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0006914 [autophagy] GO:0032456 [endocytic recycling] GO:0097352 [autophagosome maturation] Show all	2579 aa 292.5 kDa	No	0
EPG5-009 ENSP00000467066 ENST00000590854	K7ENS1 [Direct mapping] Ectopic P granules protein 5 homolog Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0006914 [autophagy] GO:0097352 [autophagosome maturation] Show all	505 aa 56.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.