Expression of SPC25 in cancer - Summary

CANCER ATLAS

Gene description

SPC25, NDC80 kinetochore complex component

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Testis cancer

STAINING SUMMARY

HPA047144

GENE INFORMATION
Gene name	SPC25 (HGNC Symbol)
Synonyms	AD024, MGC22228, SPBC25
Description	SPC25, NDC80 kinetochore complex component (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband
Chromosome location (bp)	168834132 - 168913371
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152253 (version 83.38)
Entrez gene	57405
UniProt	Q9HBM1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HBM1
Antibodypedia	SPC25 antibodies

PROTEIN BROWSER

SPC25-001	SPC25-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPC25-001 ENSP00000282074 ENST00000282074	Q9HBM1 [Direct mapping] Kinetochore protein Spc25 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000777 [condensed chromosome kinetochore] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007052 [mitotic spindle organization] GO:0007059 [chromosome segregation] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0031262 [Ndc80 complex] GO:0051301 [cell division] Show all	224 aa 26.2 kDa	No	0
SPC25-004 ENSP00000393322 ENST00000451987	C9JW94 [Direct mapping] Kinetochore protein Spc25 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		115 aa 13.6 kDa	No	0