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Several cases of colorectal, ovarian, endometrial, skin, testicular, urothelial, pancreatic and liver cancers showed moderate cytoplasmic staining. Distinct membranous positivity was observed in a few cases of liver and colorectal cancers. Rare case of colorectal and urothelial cancers displayed strong cytoplasmic staining. Remaining cancer cells were weakly stained or negative.
GENE INFORMATION
Gene name
ZFP36L2 (HGNC Symbol)
Synonyms
BRF2, ERF2, RNF162C, TIS11D
Description
ZFP36 ring finger protein-like 2 (HGNC Symbol)
Entrez gene summary
This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]
P47974 [Direct mapping] Zinc finger protein 36, C3H1 type-like 2
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Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006402 [mRNA catabolic process] GO:0008283 [cell proliferation] GO:0017091 [AU-rich element binding] GO:0030097 [hemopoiesis] GO:0033077 [T cell differentiation in thymus] GO:0035019 [somatic stem cell population maintenance] GO:0035925 [mRNA 3'-UTR AU-rich region binding] GO:0043488 [regulation of mRNA stability] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] GO:0048103 [somatic stem cell division] GO:0060216 [definitive hemopoiesis] GO:1900153 [positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:2000737 [negative regulation of stem cell differentiation]
