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This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]
P47974 [Direct mapping] Zinc finger protein 36, C3H1 type-like 2
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Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006402 [mRNA catabolic process] GO:0008283 [cell proliferation] GO:0017091 [AU-rich element binding] GO:0030097 [hemopoiesis] GO:0033077 [T cell differentiation in thymus] GO:0035019 [somatic stem cell population maintenance] GO:0035925 [mRNA 3'-UTR AU-rich region binding] GO:0043488 [regulation of mRNA stability] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] GO:0048103 [somatic stem cell division] GO:0060216 [definitive hemopoiesis] GO:1900153 [positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:2000737 [negative regulation of stem cell differentiation]
