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Several gliomas and prostate cancers along with a few duct carcinomas of breast along with adenocarcinomas of lung, pancreas, colon and stomach showed moderate cytoplasmic immunoreactivity. Remaining cancer tissues were generally negative.
A majority of tumour tissues exhibited moderate cytoplasmic and membranous positivity. Most cases of gliomas and melanomas as well as skin, renal, prostate, testicular and urothelial cancers were negative.
This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
