Cell atlas - MEPE - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MEPE

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	MEPE
Gene description	Matrix extracellular phosphoglycoprotein
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Not detected
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	MEPE
Synonyms
Description	Matrix extracellular phosphoglycoprotein (HGNC Symbol)
Entrez gene summary	This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Chromosome	4
Cytoband	q22.1
Chromosome location (bp)	87821411 - 87846817
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152595 (version 83.38)
Entrez gene	56955
UniProt	Q9NQ76 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NQ76
Antibodypedia	MEPE antibodies

PROTEIN BROWSER

MEPE-001	MEPE-002	MEPE-003	MEPE-004	MEPE-201	MEPE-202	MEPE-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MEPE-001 ENSP00000378534 ENST00000395102	Q9NQ76 [Direct mapping] Matrix extracellular phosphoglycoprotein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0001501 [skeletal system development] GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0030502 [negative regulation of bone mineralization] GO:0031214 [biomineral tissue development] GO:0046850 [regulation of bone remodeling] GO:1990430 [extracellular matrix protein binding] Show all	556 aa 62.2 kDa	Yes	0
MEPE-002 ENSP00000354341 ENST00000361056	Q9NQ76 [Direct mapping] Matrix extracellular phosphoglycoprotein A0A024RDD1 [Target identity:100%; Query identity:100%] Matrix, extracellular phosphoglycoprotein with ASARM motif (Bone), isoform CRA_b Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0031214 [biomineral tissue development] GO:1990430 [extracellular matrix protein binding] Show all	525 aa 58.4 kDa	Yes	0
MEPE-003 ENSP00000422747 ENST00000497649	D6RAC8 [Direct mapping] Matrix extracellular phosphoglycoprotein Show all	Predicted intracellular proteins Show all		501 aa 55.7 kDa	No	0
MEPE-004 ENSP00000421430 ENST00000511670	D6RFW6 [Direct mapping] Matrix extracellular phosphoglycoprotein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		96 aa 10.6 kDa	Yes	0
MEPE-201 ENSP00000416984 ENST00000424957	Q9NQ76 [Direct mapping] Matrix extracellular phosphoglycoprotein A0A024RDD1 [Target identity:100%; Query identity:100%] Matrix, extracellular phosphoglycoprotein with ASARM motif (Bone), isoform CRA_b Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0031214 [biomineral tissue development] GO:1990430 [extracellular matrix protein binding] Show all	525 aa 58.4 kDa	Yes	0
MEPE-202 ENSP00000443491 ENST00000540395	Q9NQ76 [Direct mapping] Matrix extracellular phosphoglycoprotein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0031214 [biomineral tissue development] GO:1990430 [extracellular matrix protein binding] Show all	412 aa 45.3 kDa	No	0
MEPE-203 ENSP00000453994 ENST00000560249	Q9NQ76 [Direct mapping] Matrix extracellular phosphoglycoprotein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0031214 [biomineral tissue development] GO:1990430 [extracellular matrix protein binding] Show all	412 aa 45.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.