Expression of NADK2 in cancer - Summary

CANCER ATLAS

Gene description

NAD kinase 2, mitochondrial

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA038366	HPA038367	HPA061492

GENE INFORMATION
Gene name	NADK2 (HGNC Symbol)
Synonyms	C5orf33, FLJ30596, MNADK, NADKD1
Description	NAD kinase 2, mitochondrial (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrial kinase that catalyzes the phosphorylation of NAD to yield NADP. Mutations in this gene result in 2,4-dienoyl-CoA reductase deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Chromosome	5
Cytoband	p13.2
Chromosome location (bp)	36192592 - 36242279
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152620 (version 83.38)
Entrez gene	133686
UniProt	Q4G0N4 (UniProt - Evidence at protein level)
neXtProt	NX_Q4G0N4
Antibodypedia	NADK2 antibodies

PROTEIN BROWSER

NADK2-001	NADK2-002	NADK2-003	NADK2-004	NADK2-007	NADK2-009	NADK2-010	NADK2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NADK2-001 ENSP00000380499 ENST00000397338	Q4G0N4 [Direct mapping] NAD kinase 2, mitochondrial A0A024R048 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003951 [NAD+ kinase activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0006741 [NADP biosynthetic process] GO:0016310 [phosphorylation] GO:0019674 [NAD metabolic process] GO:0042803 [protein homodimerization activity] Show all	279 aa 31.7 kDa	No	0
NADK2-002 ENSP00000422250 ENST00000506945	B7Z8V7 [Direct mapping] NAD kinase 2, mitochondrial; cDNA FLJ55867 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003951 [NAD+ kinase activity] GO:0016310 [phosphorylation] GO:0019674 [NAD metabolic process] Show all	301 aa 34.2 kDa	No	0
NADK2-003 ENSP00000371362 ENST00000381937	Q4G0N4 [Direct mapping] NAD kinase 2, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003951 [NAD+ kinase activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0006741 [NADP biosynthetic process] GO:0008152 [metabolic process] GO:0016310 [phosphorylation] GO:0019674 [NAD metabolic process] GO:0042803 [protein homodimerization activity] Show all	442 aa 49.4 kDa	No	0
NADK2-004 ENSP00000421029 ENST00000514504	Q4G0N4 [Direct mapping] NAD kinase 2, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003951 [NAD+ kinase activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0006741 [NADP biosynthetic process] GO:0008152 [metabolic process] GO:0016310 [phosphorylation] GO:0019674 [NAD metabolic process] GO:0042803 [protein homodimerization activity] Show all	410 aa 46 kDa	No	0
NADK2-007 ENSP00000426084 ENST00000511088	D6RHI4 [Direct mapping] NAD kinase 2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003951 [NAD+ kinase activity] GO:0016310 [phosphorylation] Show all	82 aa 9.6 kDa	No	0
NADK2-009 ENSP00000424166 ENST00000502355	H0Y9H7 [Direct mapping] NAD kinase 2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003951 [NAD+ kinase activity] GO:0016310 [phosphorylation] GO:0019674 [NAD metabolic process] Show all	137 aa 15.3 kDa	No	0
NADK2-010 ENSP00000282512 ENST00000282512	Q4G0N4 [Direct mapping] NAD kinase 2, mitochondrial A0A024R048 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003951 [NAD+ kinase activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0006741 [NADP biosynthetic process] GO:0016310 [phosphorylation] GO:0019674 [NAD metabolic process] GO:0042803 [protein homodimerization activity] Show all	279 aa 31.7 kDa	No	0
NADK2-201 ENSP00000480506 ENST00000617628	A0A0C4DGV3 [Direct mapping] NAD kinase 2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003951 [NAD+ kinase activity] GO:0016310 [phosphorylation] GO:0019674 [NAD metabolic process] Show all	247 aa 28.3 kDa	No	0