Tissue expression of GPD1L - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GPD1L
Gene description	Glycerol-3-phosphate dehydrogenase 1-like
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	GPD1L (HGNC Symbol)
Synonyms	KIAA0089
Description	Glycerol-3-phosphate dehydrogenase 1-like (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene catalyzes the conversion of sn-glycerol 3-phosphate to glycerone phosphate. The encoded protein is found in the cytoplasm, associated with the plasma membrane, where it binds the sodium channel, voltage-gated, type V, alpha subunit (SCN5A). Defects in this gene are a cause of Brugada syndrome type 2 (BRS2) as well as sudden infant death syndrome (SIDS). [provided by RefSeq, Jul 2010]
Chromosome	3
Cytoband	p22.3
Chromosome location (bp)	32105689 - 32168713
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152642 (version 83.38)
Entrez gene	23171
UniProt	Q8N335 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N335
Antibodypedia	GPD1L antibodies

PROTEIN BROWSER

GPD1L-001	GPD1L-003	GPD1L-005	GPD1L-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPD1L-001 ENSP00000282541 ENST00000282541	Q8N335 [Direct mapping] Glycerol-3-phosphate dehydrogenase 1-like protein Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002027 [regulation of heart rate] GO:0004367 [glycerol-3-phosphate dehydrogenase [NAD+] activity] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006072 [glycerol-3-phosphate metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006654 [phosphatidic acid biosynthetic process] GO:0006734 [NADH metabolic process] GO:0009331 [glycerol-3-phosphate dehydrogenase complex] GO:0010765 [positive regulation of sodium ion transport] GO:0016020 [membrane] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0017080 [sodium channel regulator activity] GO:0019432 [triglyceride biosynthetic process] GO:0019674 [NAD metabolic process] GO:0033137 [negative regulation of peptidyl-serine phosphorylation] GO:0042803 [protein homodimerization activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0044325 [ion channel binding] GO:0046168 [glycerol-3-phosphate catabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] GO:0060373 [regulation of ventricular cardiac muscle cell membrane depolarization] GO:0070062 [extracellular exosome] GO:0086005 [ventricular cardiac muscle cell action potential] GO:0090038 [negative regulation of protein kinase C signaling] GO:2000010 [positive regulation of protein localization to cell surface] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	351 aa 38.4 kDa	No	0
GPD1L-003 ENSP00000416518 ENST00000431009	C9JFA7 [Direct mapping] Glycerol-3-phosphate dehydrogenase 1-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004367 [glycerol-3-phosphate dehydrogenase [NAD+] activity] GO:0009331 [glycerol-3-phosphate dehydrogenase complex] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0046168 [glycerol-3-phosphate catabolic process] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	144 aa 16 kDa	No	0
GPD1L-005 ENSP00000393861 ENST00000429432	C9K0P5 [Direct mapping] Glycerol-3-phosphate dehydrogenase 1-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004367 [glycerol-3-phosphate dehydrogenase [NAD+] activity] GO:0009331 [glycerol-3-phosphate dehydrogenase complex] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0046168 [glycerol-3-phosphate catabolic process] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	128 aa 14.2 kDa	No	0
GPD1L-006 ENSP00000408770 ENST00000425459	C9JM46 [Direct mapping] Glycerol-3-phosphate dehydrogenase [NAD(+)] Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004367 [glycerol-3-phosphate dehydrogenase [NAD+] activity] GO:0005975 [carbohydrate metabolic process] GO:0009331 [glycerol-3-phosphate dehydrogenase complex] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0046168 [glycerol-3-phosphate catabolic process] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	173 aa 18.6 kDa	No	0