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DDX4

CANCER ATLAS

Gene description

 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037763
HPA037764
CAB026170

GENE INFORMATION

Gene name

 DDX4 (HGNC Symbol)

Synonyms

 VASA

Description

 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 (HGNC Symbol)

Entrez gene summary

 DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Chromosome

 5

Cytoband

 q11.2

Chromosome location (bp)

 55738017 - 55817157

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152670 (version 83.38)

Entrez gene

 54514

UniProt

 Q9NQI0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NQI0

Antibodypedia

 DDX4 antibodies

PROTEIN BROWSER
DDX4-001
DDX4-002
DDX4-003
DDX4-005
DDX4-006
DDX4-007
DDX4-008
DDX4-009
DDX4-201
DDX4-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DDX4-001
ENSP00000424838
ENST00000505374
Q9NQI0 [Direct mapping]
Probable ATP-dependent RNA helicase DDX4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007141 [male meiosis I]
GO:0007275 [multicellular organismal development]
GO:0007283 [spermatogenesis]
GO:0010467 [gene expression]
GO:0010501 [RNA secondary structure unwinding]
GO:0030317 [sperm motility]
GO:0030529 [ribonucleoprotein complex]
GO:0031047 [gene silencing by RNA]
GO:0032880 [regulation of protein localization]
GO:0034587 [piRNA metabolic process]
GO:0043186 [P granule]
GO:0048471 [perinuclear region of cytoplasm]
GO:0071546 [pi-body]
GO:0071547 [piP-body]
Show all
 724 aa
79.3 kDa 		No 0
DDX4-002
ENSP00000427167
ENST00000506511
D6RCM4 [Direct mapping]
Probable ATP-dependent RNA helicase DDX4
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0010501 [RNA secondary structure unwinding]
GO:0043186 [P granule]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 518 aa
56.5 kDa 		No 0
DDX4-003
ENSP00000347087
ENST00000354991
Q9NQI0 [Direct mapping]
Probable ATP-dependent RNA helicase DDX4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0007275 [multicellular organismal development]
GO:0010467 [gene expression]
GO:0010501 [RNA secondary structure unwinding]
GO:0030317 [sperm motility]
GO:0031047 [gene silencing by RNA]
GO:0034587 [piRNA metabolic process]
GO:0043186 [P granule]
GO:0048471 [perinuclear region of cytoplasm]
GO:0071546 [pi-body]
GO:0071547 [piP-body]
Show all
 690 aa
75.8 kDa 		No 0
DDX4-005
ENSP00000423123
ENST00000511853
Q9NQI0 [Direct mapping]
Probable ATP-dependent RNA helicase DDX4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0007275 [multicellular organismal development]
GO:0010467 [gene expression]
GO:0010501 [RNA secondary structure unwinding]
GO:0030317 [sperm motility]
GO:0031047 [gene silencing by RNA]
GO:0034587 [piRNA metabolic process]
GO:0043186 [P granule]
GO:0048471 [perinuclear region of cytoplasm]
GO:0071546 [pi-body]
GO:0071547 [piP-body]
Show all
 575 aa
63.2 kDa 		No 0
DDX4-006
ENSP00000421960
ENST00000506848
D6RAF5 [Direct mapping]
Probable ATP-dependent RNA helicase DDX4
Show all
Predicted intracellular proteins
Show all
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0010501 [RNA secondary structure unwinding]
GO:0043186 [P granule]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 105 aa
11.6 kDa 		No 0
DDX4-007
ENSP00000424112
ENST00000514679
D6RBL3 [Direct mapping]
Probable ATP-dependent RNA helicase DDX4
Show all
Predicted intracellular proteins
Show all
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0010501 [RNA secondary structure unwinding]
GO:0043186 [P granule]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 159 aa
17.5 kDa 		No 0
DDX4-008
ENSP00000427522
ENST00000511491
D6RIB2 [Direct mapping]
Probable ATP-dependent RNA helicase DDX4
Show all
Predicted intracellular proteins
Show all
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0010501 [RNA secondary structure unwinding]
GO:0043186 [P granule]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 156 aa
17.3 kDa 		No 0
DDX4-009
ENSP00000424779
ENST00000515709
D6RAT7 [Direct mapping]
Probable ATP-dependent RNA helicase DDX4
Show all
Predicted intracellular proteins
Show all
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0010501 [RNA secondary structure unwinding]
GO:0043186 [P granule]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 142 aa
15.5 kDa 		No 0
DDX4-201
ENSP00000334167
ENST00000353507
Q9NQI0 [Direct mapping]
Probable ATP-dependent RNA helicase DDX4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0007275 [multicellular organismal development]
GO:0010467 [gene expression]
GO:0010501 [RNA secondary structure unwinding]
GO:0030317 [sperm motility]
GO:0031047 [gene silencing by RNA]
GO:0034587 [piRNA metabolic process]
GO:0043186 [P granule]
GO:0048471 [perinuclear region of cytoplasm]
GO:0071546 [pi-body]
GO:0071547 [piP-body]
Show all
 690 aa
75.8 kDa 		No 0
DDX4-202
ENSP00000425359
ENST00000514278
Q9NQI0 [Direct mapping]
Probable ATP-dependent RNA helicase DDX4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0007275 [multicellular organismal development]
GO:0010467 [gene expression]
GO:0010501 [RNA secondary structure unwinding]
GO:0030317 [sperm motility]
GO:0031047 [gene silencing by RNA]
GO:0034587 [piRNA metabolic process]
GO:0043186 [P granule]
GO:0048471 [perinuclear region of cytoplasm]
GO:0071546 [pi-body]
GO:0071547 [piP-body]
Show all
 704 aa
77.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.