Expression of SLC30A6 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 30 (zinc transporter), member 6

Protein class

Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA057328

GENE INFORMATION
Gene name	SLC30A6 (HGNC Symbol)
Synonyms	FLJ31101, ZNT6
Description	Solute carrier family 30 (zinc transporter), member 6 (HGNC Symbol)
Entrez gene summary	Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A6, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008]
Chromosome	2
Cytoband	p22.3
Chromosome location (bp)	32165841 - 32224379
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152683 (version 83.38)
Entrez gene	55676
UniProt	Q6NXT4 (UniProt - Evidence at protein level)
neXtProt	NX_Q6NXT4
Antibodypedia	SLC30A6 antibodies

PROTEIN BROWSER

SLC30A6-001	SLC30A6-002	SLC30A6-005	SLC30A6-006	SLC30A6-201	SLC30A6-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC30A6-001 ENSP00000282587 ENST00000282587	Q6NXT4 [Direct mapping] Zinc transporter 6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005385 [zinc ion transmembrane transporter activity] GO:0005794 [Golgi apparatus] GO:0006812 [cation transport] GO:0008324 [cation transmembrane transporter activity] GO:0010043 [response to zinc ion] GO:0016021 [integral component of membrane] GO:0044267 [cellular protein metabolic process] GO:0055085 [transmembrane transport] GO:0061088 [regulation of sequestering of zinc ion] GO:0071577 [zinc II ion transmembrane transport] Show all	461 aa 51.1 kDa	No	6
SLC30A6-002 ENSP00000368648 ENST00000379343	Q6NXT4 [Direct mapping] Zinc transporter 6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005385 [zinc ion transmembrane transporter activity] GO:0005739 [mitochondrion] GO:0005794 [Golgi apparatus] GO:0006812 [cation transport] GO:0008324 [cation transmembrane transporter activity] GO:0010043 [response to zinc ion] GO:0016021 [integral component of membrane] GO:0044267 [cellular protein metabolic process] GO:0055085 [transmembrane transport] GO:0061088 [regulation of sequestering of zinc ion] GO:0071577 [zinc II ion transmembrane transport] Show all	501 aa 55.8 kDa	No	6
SLC30A6-005 ENSP00000384041 ENST00000406369	B5MCR8 [Direct mapping] Solute carrier family 30 (Zinc transporter), member 6, isoform CRA_b; Zinc transporter 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0006812 [cation transport] GO:0008324 [cation transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] Show all	387 aa 42.5 kDa	No	4
SLC30A6-006 ENSP00000393946 ENST00000440718	C9JZR9 [Direct mapping] Zinc transporter 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006812 [cation transport] GO:0008324 [cation transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] Show all	179 aa 20 kDa	No	4
SLC30A6-201 ENSP00000349563 ENST00000357055	Q6NXT4 [Direct mapping] Zinc transporter 6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005385 [zinc ion transmembrane transporter activity] GO:0005794 [Golgi apparatus] GO:0006812 [cation transport] GO:0008324 [cation transmembrane transporter activity] GO:0010043 [response to zinc ion] GO:0016021 [integral component of membrane] GO:0044267 [cellular protein metabolic process] GO:0055085 [transmembrane transport] GO:0061088 [regulation of sequestering of zinc ion] GO:0071577 [zinc II ion transmembrane transport] Show all	432 aa 47.6 kDa	No	6
SLC30A6-202 ENSP00000399005 ENST00000435660	Q6NXT4 [Direct mapping] Zinc transporter 6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005385 [zinc ion transmembrane transporter activity] GO:0005794 [Golgi apparatus] GO:0006812 [cation transport] GO:0008324 [cation transmembrane transporter activity] GO:0010043 [response to zinc ion] GO:0016021 [integral component of membrane] GO:0044267 [cellular protein metabolic process] GO:0055085 [transmembrane transport] GO:0061088 [regulation of sequestering of zinc ion] GO:0071577 [zinc II ion transmembrane transport] Show all	438 aa 48.6 kDa	No	6