Cell atlas - BANK1 - The Human Protein Atlas

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BANK1

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm
	Plasma membrane

Human cell
	Cytosol
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	BANK1
Gene description	B-cell scaffold protein with ankyrin repeats 1
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & cytosol. In addition localized to the nucleoplasm.
RNA cell category	Cell line enhanced (U-266/70, Daudi, HEL)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Cytosol (approved)
Additional location	In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA037002
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-266/70, Daudi, HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & cytosol. In addition localized to the nucleoplasm.

Main location

Plasma membrane (approved), Cytosol (approved)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA037002	PC-3	Nucleoplasm
	HPA037002	PC-3	Plasma membrane
	HPA037002	RT4	Nucleoplasm
			Plasma membrane
			Cytosol
	HPA037002	U-2 OS	Nucleoplasm
	HPA037002	U-2 OS	Cytosol

GENE INFORMATION
Gene name	BANK1 (HGNC Symbol)
Synonyms	BANK, FLJ20706
Description	B-cell scaffold protein with ankyrin repeats 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Chromosome	4
Cytoband	q24
Chromosome location (bp)	101411286 - 102074812
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153064 (version 83.38)
Entrez gene	55024
UniProt	Q8NDB2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NDB2
Antibodypedia	BANK1 antibodies

PROTEIN BROWSER

BANK1-001	BANK1-002	BANK1-003	BANK1-004	BANK1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BANK1-001 ENSP00000320509 ENST00000322953	Q8NDB2 [Direct mapping] B-cell scaffold protein with ankyrin repeats Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0042113 [B cell activation] GO:0043410 [positive regulation of MAPK cascade] GO:0045947 [negative regulation of translational initiation] GO:0050869 [negative regulation of B cell activation] GO:0051898 [negative regulation of protein kinase B signaling] GO:1900165 [negative regulation of interleukin-6 secretion] Show all	785 aa 89.3 kDa	No	0
BANK1-002 ENSP00000422314 ENST00000508653	Q8NDB2 [Direct mapping] B-cell scaffold protein with ankyrin repeats Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0042113 [B cell activation] Show all	652 aa 73.7 kDa	No	0
BANK1-003 ENSP00000388817 ENST00000444316	Q8NDB2 [Direct mapping] B-cell scaffold protein with ankyrin repeats Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0042113 [B cell activation] Show all	755 aa 86.5 kDa	No	0
BANK1-004 ENSP00000421443 ENST00000504592	Q8NDB2 [Direct mapping] B-cell scaffold protein with ankyrin repeats Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0042113 [B cell activation] Show all	770 aa 88.1 kDa	No	0
BANK1-201 ENSP00000412748 ENST00000428908	Q8NDB2 [Direct mapping] B-cell scaffold protein with ankyrin repeats Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0042113 [B cell activation] Show all	652 aa 73.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.