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RNA tissue category: Group enriched (spleen, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, appendix, tonsil, lymph node)
GENE INFORMATION
Gene name
BANK1 (HGNC Symbol)
Synonyms
BANK, FLJ20706
Description
B-cell scaffold protein with ankyrin repeats 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Q8NDB2 [Direct mapping] B-cell scaffold protein with ankyrin repeats
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Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding] GO:0042113 [B cell activation] GO:0043410 [positive regulation of MAPK cascade] GO:0045947 [negative regulation of translational initiation] GO:0050869 [negative regulation of B cell activation] GO:0051898 [negative regulation of protein kinase B signaling] GO:1900165 [negative regulation of interleukin-6 secretion]
