Cell atlas - PLEKHG4B - The Human Protein Atlas

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PLEKHG4B

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PLEKHG4B
Gene description	Pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Cell line enhanced (REH, T-47d, SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA058157
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (REH, T-47d, SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA058157	RH-30	Nucleoplasm
	HPA058157	SiHa	Nucleoplasm
	HPA058157	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	PLEKHG4B (HGNC Symbol)
Synonyms	KIAA1909
Description	Pleckstrin homology domain containing, family G (with RhoGef domain) member 4B (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	p15.33
Chromosome location (bp)	140258 - 189970
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153404 (version 83.38)
Entrez gene	153478
UniProt	Q96PX9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96PX9
Antibodypedia	PLEKHG4B antibodies

PROTEIN BROWSER

PLEKHG4B-001	PLEKHG4B-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLEKHG4B-001 ENSP00000283426 ENST00000283426	Q96PX9 [Direct mapping] Pleckstrin homology domain-containing family G member 4B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	1271 aa 139.7 kDa	No	0
PLEKHG4B-002 ENSP00000422493 ENST00000502646	Q96HN1 [Direct mapping] PLEKHG4B protein; Pleckstrin homology domain-containing family G member 4B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		421 aa 45.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.