Fields »
ABOUT
HELP
BLOG
DDAH1

CANCER ATLAS

Gene description

 Dimethylarginine dimethylaminohydrolase 1

Protein class

 Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006308

GENE INFORMATION

Gene name

 DDAH1 (HGNC Symbol)

Synonyms

 DDAH

Description

 Dimethylarginine dimethylaminohydrolase 1 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p22.3

Chromosome location (bp)

 85318481 - 85578363

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000153904 (version 83.38)

Entrez gene

 23576

UniProt

 O94760 (UniProt - Evidence at protein level)

neXtProt

 NX_O94760

Antibodypedia

 DDAH1 antibodies

PROTEIN BROWSER
DDAH1-001
DDAH1-009
DDAH1-010
DDAH1-201
DDAH1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DDAH1-001
ENSP00000284031
ENST00000284031
O94760 [Direct mapping]
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
B1AKK2 [Target identity:100%; Query identity:100%]
Dimethylarginine dimethylaminohydrolase 1, isoform CRA_b; Epididymis secretory protein Li 16; cDNA, FLJ92778, Homo sapiens dimethylarginine dimethylaminohydrolase 1 (DDAH1), mRNA
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000052 [citrulline metabolic process]
GO:0003073 [regulation of systemic arterial blood pressure]
GO:0003824 [catalytic activity]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006525 [arginine metabolic process]
GO:0006527 [arginine catabolic process]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0016403 [dimethylargininase activity]
GO:0016597 [amino acid binding]
GO:0044281 [small molecule metabolic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0046209 [nitric oxide metabolic process]
GO:0046872 [metal ion binding]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0070062 [extracellular exosome]
Show all
 285 aa
31.1 kDa 		No 0
DDAH1-009
ENSP00000439045
ENST00000535924
O94760 [Direct mapping]
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000052 [citrulline metabolic process]
GO:0003073 [regulation of systemic arterial blood pressure]
GO:0003824 [catalytic activity]
GO:0005829 [cytosol]
GO:0006527 [arginine catabolic process]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0016403 [dimethylargininase activity]
GO:0044281 [small molecule metabolic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0046209 [nitric oxide metabolic process]
GO:0046872 [metal ion binding]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0070062 [extracellular exosome]
Show all
 182 aa
20.2 kDa 		No 0
DDAH1-010
ENSP00000488725
ENST00000633113
B4DYP1 [Target identity:100%; Query identity:100%]
cDNA FLJ54119, highly similar to NG,NG-dimethylarginine dimethylaminohydrolase 1 (EC 3.5.3.18)
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
Show all
 185 aa
20.5 kDa 		No 0
DDAH1-201
ENSP00000411189
ENST00000426972
O94760 [Direct mapping]
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000052 [citrulline metabolic process]
GO:0003073 [regulation of systemic arterial blood pressure]
GO:0003824 [catalytic activity]
GO:0005829 [cytosol]
GO:0006527 [arginine catabolic process]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0016403 [dimethylargininase activity]
GO:0044281 [small molecule metabolic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0046209 [nitric oxide metabolic process]
GO:0046872 [metal ion binding]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0070062 [extracellular exosome]
Show all
 182 aa
20.2 kDa 		No 0
DDAH1-202
ENSP00000438604
ENST00000539042
O94760 [Direct mapping]
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
B1AKK2 [Target identity:100%; Query identity:100%]
Dimethylarginine dimethylaminohydrolase 1, isoform CRA_b; Epididymis secretory protein Li 16; cDNA, FLJ92778, Homo sapiens dimethylarginine dimethylaminohydrolase 1 (DDAH1), mRNA
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000052 [citrulline metabolic process]
GO:0003073 [regulation of systemic arterial blood pressure]
GO:0003824 [catalytic activity]
GO:0005829 [cytosol]
GO:0006527 [arginine catabolic process]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0016403 [dimethylargininase activity]
GO:0044281 [small molecule metabolic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0046209 [nitric oxide metabolic process]
GO:0046872 [metal ion binding]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0070062 [extracellular exosome]
Show all
 285 aa
31.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.