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CABYR

CANCER ATLAS

Gene description

 Calcium binding tyrosine-(Y)-phosphorylation regulated

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040703
HPA047801

GENE INFORMATION

Gene name

 CABYR (HGNC Symbol)

Synonyms

 CBP86, CT88, FSP-2

Description

 Calcium binding tyrosine-(Y)-phosphorylation regulated (HGNC Symbol)

Entrez gene summary

 To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

Chromosome

 18

Cytoband

 q11.2

Chromosome location (bp)

 24138956 - 24161603

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154040 (version 83.38)

Entrez gene

 26256

UniProt

 O75952 (UniProt - Evidence at protein level)

neXtProt

 NX_O75952

Antibodypedia

 CABYR antibodies

PROTEIN BROWSER
«
CABYR-001
CABYR-002
CABYR-003
CABYR-004
CABYR-005
CABYR-006
CABYR-007
CABYR-008
CABYR-009
CABYR-010
CABYR-014
CABYR-015
CABYR-016
CABYR-017
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CABYR-001
ENSP00000382419
ENST00000399496
O75952 [Direct mapping]
Calcium-binding tyrosine phosphorylation-regulated protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003351 [epithelial cilium movement]
GO:0005509 [calcium ion binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0017124 [SH3 domain binding]
GO:0019899 [enzyme binding]
GO:0031514 [motile cilium]
GO:0035686 [sperm fibrous sheath]
GO:0046982 [protein heterodimerization activity]
GO:0048240 [sperm capacitation]
Show all
 379 aa
41.1 kDa 		No 0
CABYR-002
ENSP00000483621
ENST00000621648
O75952 [Direct mapping]
Calcium-binding tyrosine phosphorylation-regulated protein
A0A024RC21 [Target identity:100%; Query identity:100%]
Calcium binding tyrosine-(Y)-phosphorylation regulated (Fibrousheathin 2), isoform CRA_c
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003351 [epithelial cilium movement]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0017124 [SH3 domain binding]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0031514 [motile cilium]
GO:0035686 [sperm fibrous sheath]
GO:0046982 [protein heterodimerization activity]
GO:0048240 [sperm capacitation]
GO:0097228 [sperm principal piece]
GO:0097229 [sperm end piece]
Show all
 493 aa
52.8 kDa 		No 0
CABYR-003
ENSP00000382404
ENST00000399481
O75952 [Direct mapping]
Calcium-binding tyrosine phosphorylation-regulated protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003351 [epithelial cilium movement]
GO:0005509 [calcium ion binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0017124 [SH3 domain binding]
GO:0019899 [enzyme binding]
GO:0031514 [motile cilium]
GO:0035686 [sperm fibrous sheath]
GO:0046982 [protein heterodimerization activity]
GO:0048240 [sperm capacitation]
Show all
 475 aa
50.7 kDa 		No 0
CABYR-004
ENSP00000317095
ENST00000327201
O75952 [Direct mapping]
Calcium-binding tyrosine phosphorylation-regulated protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003351 [epithelial cilium movement]
GO:0005509 [calcium ion binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0017124 [SH3 domain binding]
GO:0019899 [enzyme binding]
GO:0031514 [motile cilium]
GO:0035686 [sperm fibrous sheath]
GO:0046982 [protein heterodimerization activity]
GO:0048240 [sperm capacitation]
Show all
 281 aa
30.1 kDa 		No 0
CABYR-005
ENSP00000399973
ENST00000415309
O75952 [Direct mapping]
Calcium-binding tyrosine phosphorylation-regulated protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003351 [epithelial cilium movement]
GO:0005509 [calcium ion binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0017124 [SH3 domain binding]
GO:0019899 [enzyme binding]
GO:0031514 [motile cilium]
GO:0035686 [sperm fibrous sheath]
GO:0046982 [protein heterodimerization activity]
GO:0048240 [sperm capacitation]
Show all
 221 aa
24 kDa 		No 0
CABYR-006
ENSP00000382421
ENST00000399499
O75952 [Direct mapping]
Calcium-binding tyrosine phosphorylation-regulated protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003351 [epithelial cilium movement]
GO:0005509 [calcium ion binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0017124 [SH3 domain binding]
GO:0019899 [enzyme binding]
GO:0031514 [motile cilium]
GO:0035686 [sperm fibrous sheath]
GO:0046982 [protein heterodimerization activity]
GO:0048240 [sperm capacitation]
Show all
 379 aa
41.1 kDa 		No 0
CABYR-007
ENSP00000463737
ENST00000585037
J3QLW5 [Direct mapping]
Calcium-binding tyrosine phosphorylation-regulated protein
Show all
Predicted intracellular proteins
Show all
 46 aa
5 kDa 		No 0
CABYR-008
ENSP00000462748
ENST00000579102
J3KT09 [Direct mapping]
Calcium-binding tyrosine phosphorylation-regulated protein
Show all
Predicted intracellular proteins
Show all
 84 aa
9.6 kDa 		No 0
CABYR-009
ENSP00000462947
ENST00000582229
J3KTE8 [Direct mapping]
Calcium-binding tyrosine phosphorylation-regulated protein
Show all
Predicted intracellular proteins
Show all
 293 aa
30.9 kDa 		No 0
CABYR-010
ENSP00000463781
ENST00000577705
J3QQK7 [Direct mapping]
Calcium-binding tyrosine phosphorylation-regulated protein
Show all
Predicted intracellular proteins
Show all
 36 aa
4.1 kDa 		No 0
CABYR-014
ENSP00000432870
ENST00000463087
O75952 [Direct mapping]
Calcium-binding tyrosine phosphorylation-regulated protein
A0A024RC21 [Target identity:100%; Query identity:100%]
Calcium binding tyrosine-(Y)-phosphorylation regulated (Fibrousheathin 2), isoform CRA_c
Show all
Predicted intracellular proteins
Show all
GO:0003351 [epithelial cilium movement]
GO:0005509 [calcium ion binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0017124 [SH3 domain binding]
GO:0019899 [enzyme binding]
GO:0031514 [motile cilium]
GO:0035686 [sperm fibrous sheath]
GO:0046982 [protein heterodimerization activity]
GO:0048240 [sperm capacitation]
Show all
 493 aa
52.8 kDa 		No 0
CABYR-015
ENSP00000486801
ENST00000627314
A0A0D9SFQ2 [Direct mapping]
Calcium binding tyrosine-(Y)-phosphorylation regulated (Fibrousheathin 2), isoform CRA_a; Calcium-binding tyrosine phosphorylation-regulated protein
Show all
Predicted intracellular proteins
Show all
 395 aa
41.7 kDa 		No 0
CABYR-016
ENSP00000431142
ENST00000486759
O75952 [Direct mapping]
Calcium-binding tyrosine phosphorylation-regulated protein
A0A024RC21 [Target identity:100%; Query identity:100%]
Calcium binding tyrosine-(Y)-phosphorylation regulated (Fibrousheathin 2), isoform CRA_c
Show all
Predicted intracellular proteins
Show all
GO:0003351 [epithelial cilium movement]
GO:0005509 [calcium ion binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0017124 [SH3 domain binding]
GO:0019899 [enzyme binding]
GO:0031514 [motile cilium]
GO:0035686 [sperm fibrous sheath]
GO:0046982 [protein heterodimerization activity]
GO:0048240 [sperm capacitation]
Show all
 493 aa
52.8 kDa 		No 0
CABYR-017
ENSP00000462811
ENST00000581397
G9BQT7 [Direct mapping]
Calcium-binding tyrosine phosphorylation-regulated protein; Calcium-binding tyrosine phosphorylation-regulated protein isoform 8
Show all
Predicted intracellular proteins
Show all
 196 aa
21.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.