Cell atlas - CABYR - The Human Protein Atlas

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CABYR

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleus

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CABYR
Gene description	Calcium binding tyrosine-(Y)-phosphorylation regulated
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & cytosol.
RNA cell category	Cell line enhanced (SiHa)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported), Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA047801
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SiHa) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & cytosol.

Main location

Nucleus (supported), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA047801	A549	Nucleoplasm
	HPA047801	A549	Cytosol
	HPA047801	SiHa	Nucleoplasm
	HPA047801	SiHa	Cytosol
	HPA047801	U-2 OS	Nucleus
	HPA047801	U-2 OS	Cytosol

GENE INFORMATION
Gene name	CABYR (HGNC Symbol)
Synonyms	CBP86, CT88, FSP-2
Description	Calcium binding tyrosine-(Y)-phosphorylation regulated (HGNC Symbol)
Entrez gene summary	To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Chromosome	18
Cytoband	q11.2
Chromosome location (bp)	24138956 - 24161603
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154040 (version 83.38)
Entrez gene	26256
UniProt	O75952 (UniProt - Evidence at protein level)
neXtProt	NX_O75952
Antibodypedia	CABYR antibodies

PROTEIN BROWSER

CABYR-001	CABYR-002	CABYR-003	CABYR-004	CABYR-005	CABYR-006	CABYR-007	CABYR-008	CABYR-009	CABYR-010	CABYR-014	CABYR-015	CABYR-016	CABYR-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CABYR-001 ENSP00000382419 ENST00000399496	O75952 [Direct mapping] Calcium-binding tyrosine phosphorylation-regulated protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003351 [epithelial cilium movement] GO:0005509 [calcium ion binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0017124 [SH3 domain binding] GO:0019899 [enzyme binding] GO:0031514 [motile cilium] GO:0035686 [sperm fibrous sheath] GO:0046982 [protein heterodimerization activity] GO:0048240 [sperm capacitation] Show all	379 aa 41.1 kDa	No	0
CABYR-002 ENSP00000483621 ENST00000621648	O75952 [Direct mapping] Calcium-binding tyrosine phosphorylation-regulated protein A0A024RC21 [Target identity:100%; Query identity:100%] Calcium binding tyrosine-(Y)-phosphorylation regulated (Fibrousheathin 2), isoform CRA_c Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003351 [epithelial cilium movement] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0017124 [SH3 domain binding] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0031514 [motile cilium] GO:0035686 [sperm fibrous sheath] GO:0046982 [protein heterodimerization activity] GO:0048240 [sperm capacitation] GO:0097228 [sperm principal piece] GO:0097229 [sperm end piece] Show all	493 aa 52.8 kDa	No	0
CABYR-003 ENSP00000382404 ENST00000399481	O75952 [Direct mapping] Calcium-binding tyrosine phosphorylation-regulated protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003351 [epithelial cilium movement] GO:0005509 [calcium ion binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0017124 [SH3 domain binding] GO:0019899 [enzyme binding] GO:0031514 [motile cilium] GO:0035686 [sperm fibrous sheath] GO:0046982 [protein heterodimerization activity] GO:0048240 [sperm capacitation] Show all	475 aa 50.7 kDa	No	0
CABYR-004 ENSP00000317095 ENST00000327201	O75952 [Direct mapping] Calcium-binding tyrosine phosphorylation-regulated protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003351 [epithelial cilium movement] GO:0005509 [calcium ion binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0017124 [SH3 domain binding] GO:0019899 [enzyme binding] GO:0031514 [motile cilium] GO:0035686 [sperm fibrous sheath] GO:0046982 [protein heterodimerization activity] GO:0048240 [sperm capacitation] Show all	281 aa 30.1 kDa	No	0
CABYR-005 ENSP00000399973 ENST00000415309	O75952 [Direct mapping] Calcium-binding tyrosine phosphorylation-regulated protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003351 [epithelial cilium movement] GO:0005509 [calcium ion binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0017124 [SH3 domain binding] GO:0019899 [enzyme binding] GO:0031514 [motile cilium] GO:0035686 [sperm fibrous sheath] GO:0046982 [protein heterodimerization activity] GO:0048240 [sperm capacitation] Show all	221 aa 24 kDa	No	0
CABYR-006 ENSP00000382421 ENST00000399499	O75952 [Direct mapping] Calcium-binding tyrosine phosphorylation-regulated protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003351 [epithelial cilium movement] GO:0005509 [calcium ion binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0017124 [SH3 domain binding] GO:0019899 [enzyme binding] GO:0031514 [motile cilium] GO:0035686 [sperm fibrous sheath] GO:0046982 [protein heterodimerization activity] GO:0048240 [sperm capacitation] Show all	379 aa 41.1 kDa	No	0
CABYR-007 ENSP00000463737 ENST00000585037	J3QLW5 [Direct mapping] Calcium-binding tyrosine phosphorylation-regulated protein Show all	Predicted intracellular proteins Show all		46 aa 5 kDa	No	0
CABYR-008 ENSP00000462748 ENST00000579102	J3KT09 [Direct mapping] Calcium-binding tyrosine phosphorylation-regulated protein Show all	Predicted intracellular proteins Show all		84 aa 9.6 kDa	No	0
CABYR-009 ENSP00000462947 ENST00000582229	J3KTE8 [Direct mapping] Calcium-binding tyrosine phosphorylation-regulated protein Show all	Predicted intracellular proteins Show all		293 aa 30.9 kDa	No	0
CABYR-010 ENSP00000463781 ENST00000577705	J3QQK7 [Direct mapping] Calcium-binding tyrosine phosphorylation-regulated protein Show all	Predicted intracellular proteins Show all		36 aa 4.1 kDa	No	0
CABYR-014 ENSP00000432870 ENST00000463087	O75952 [Direct mapping] Calcium-binding tyrosine phosphorylation-regulated protein A0A024RC21 [Target identity:100%; Query identity:100%] Calcium binding tyrosine-(Y)-phosphorylation regulated (Fibrousheathin 2), isoform CRA_c Show all	Predicted intracellular proteins Show all	GO:0003351 [epithelial cilium movement] GO:0005509 [calcium ion binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0017124 [SH3 domain binding] GO:0019899 [enzyme binding] GO:0031514 [motile cilium] GO:0035686 [sperm fibrous sheath] GO:0046982 [protein heterodimerization activity] GO:0048240 [sperm capacitation] Show all	493 aa 52.8 kDa	No	0
CABYR-015 ENSP00000486801 ENST00000627314	A0A0D9SFQ2 [Direct mapping] Calcium binding tyrosine-(Y)-phosphorylation regulated (Fibrousheathin 2), isoform CRA_a; Calcium-binding tyrosine phosphorylation-regulated protein Show all	Predicted intracellular proteins Show all		395 aa 41.7 kDa	No	0
CABYR-016 ENSP00000431142 ENST00000486759	O75952 [Direct mapping] Calcium-binding tyrosine phosphorylation-regulated protein A0A024RC21 [Target identity:100%; Query identity:100%] Calcium binding tyrosine-(Y)-phosphorylation regulated (Fibrousheathin 2), isoform CRA_c Show all	Predicted intracellular proteins Show all	GO:0003351 [epithelial cilium movement] GO:0005509 [calcium ion binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0017124 [SH3 domain binding] GO:0019899 [enzyme binding] GO:0031514 [motile cilium] GO:0035686 [sperm fibrous sheath] GO:0046982 [protein heterodimerization activity] GO:0048240 [sperm capacitation] Show all	493 aa 52.8 kDa	No	0
CABYR-017 ENSP00000462811 ENST00000581397	G9BQT7 [Direct mapping] Calcium-binding tyrosine phosphorylation-regulated protein; Calcium-binding tyrosine phosphorylation-regulated protein isoform 8 Show all	Predicted intracellular proteins Show all		196 aa 21.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.