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ANGPT1

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GENERAL INFORMATION

Gene name

 ANGPT1

Gene description

 Angiopoietin 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (U-138 MG, HEL, WM-115)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-138 MG, HEL, WM-115)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 ANGPT1 (HGNC Symbol)

Synonyms

 Ang1, KIAA0003

Description

 Angiopoietin 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]

Chromosome

 8

Cytoband

 q23.1

Chromosome location (bp)

 107249482 - 107498055

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154188 (version 83.38)

Entrez gene

 284

UniProt

 Q15389 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15389

Antibodypedia

 ANGPT1 antibodies

PROTEIN BROWSER
ANGPT1-001
ANGPT1-002
ANGPT1-003
ANGPT1-006
ANGPT1-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANGPT1-001
ENSP00000428340
ENST00000517746
Q15389 [Direct mapping]
Angiopoietin-1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0001701 [in utero embryonic development]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002040 [sprouting angiogenesis]
GO:0002092 [positive regulation of receptor internalization]
GO:0002740 [negative regulation of cytokine secretion involved in immune response]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0007162 [negative regulation of cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014842 [regulation of satellite cell proliferation]
GO:0030097 [hemopoiesis]
GO:0030210 [heparin biosynthetic process]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031589 [cell-substrate adhesion]
GO:0032680 [regulation of tumor necrosis factor production]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034394 [protein localization to cell surface]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042308 [negative regulation of protein import into nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0043116 [negative regulation of vascular permeability]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043393 [regulation of protein binding]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045785 [positive regulation of cell adhesion]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048014 [Tie signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050900 [leukocyte migration]
GO:0050918 [positive chemotaxis]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0072012 [glomerulus vasculature development]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
GO:2000446 [regulation of macrophage migration inhibitory factor signaling pathway]
Show all
 498 aa
57.5 kDa 		Yes 0
ANGPT1-002
ENSP00000430750
ENST00000520734
B4DTQ9 [Direct mapping]
Angiopoietin-1; cDNA FLJ56604, highly similar to Angiopoietin-1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0030971 [receptor tyrosine kinase binding]
GO:0048014 [Tie signaling pathway]
Show all
 298 aa
34.3 kDa 		No 0
ANGPT1-003
ENSP00000297450
ENST00000297450
Q15389 [Direct mapping]
Angiopoietin-1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0002040 [sprouting angiogenesis]
GO:0002092 [positive regulation of receptor internalization]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0007162 [negative regulation of cell adhesion]
GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0014842 [regulation of satellite cell proliferation]
GO:0030210 [heparin biosynthetic process]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0034394 [protein localization to cell surface]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043066 [negative regulation of apoptotic process]
GO:0043116 [negative regulation of vascular permeability]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048014 [Tie signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050900 [leukocyte migration]
GO:0050918 [positive chemotaxis]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0072012 [glomerulus vasculature development]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
Show all
 497 aa
57.5 kDa 		Yes 0
ANGPT1-006
ENSP00000428908
ENST00000520033
E5RFF4 [Direct mapping]
Angiopoietin-1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0030971 [receptor tyrosine kinase binding]
GO:0048014 [Tie signaling pathway]
Show all
 30 aa
3.3 kDa 		No 0
ANGPT1-009
ENSP00000429349
ENST00000520052
E7ERK4 [Direct mapping]
Angiopoietin-1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0030971 [receptor tyrosine kinase binding]
GO:0048014 [Tie signaling pathway]
Show all
 297 aa
34.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.