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This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001525 [angiogenesis] GO:0001701 [in utero embryonic development] GO:0001933 [negative regulation of protein phosphorylation] GO:0002040 [sprouting angiogenesis] GO:0002092 [positive regulation of receptor internalization] GO:0002740 [negative regulation of cytokine secretion involved in immune response] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005902 [microvillus] GO:0007162 [negative regulation of cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010595 [positive regulation of endothelial cell migration] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014842 [regulation of satellite cell proliferation] GO:0030097 [hemopoiesis] GO:0030210 [heparin biosynthetic process] GO:0030971 [receptor tyrosine kinase binding] GO:0031398 [positive regulation of protein ubiquitination] GO:0031589 [cell-substrate adhesion] GO:0032680 [regulation of tumor necrosis factor production] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034394 [protein localization to cell surface] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042308 [negative regulation of protein import into nucleus] GO:0043066 [negative regulation of apoptotic process] GO:0043116 [negative regulation of vascular permeability] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043393 [regulation of protein binding] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045785 [positive regulation of cell adhesion] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048014 [Tie signaling pathway] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050900 [leukocyte migration] GO:0050918 [positive chemotaxis] GO:0051897 [positive regulation of protein kinase B signaling] GO:0070062 [extracellular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0072012 [glomerulus vasculature development] GO:2000352 [negative regulation of endothelial cell apoptotic process] GO:2000446 [regulation of macrophage migration inhibitory factor signaling pathway]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0002040 [sprouting angiogenesis] GO:0002092 [positive regulation of receptor internalization] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005902 [microvillus] GO:0007162 [negative regulation of cell adhesion] GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010595 [positive regulation of endothelial cell migration] GO:0014842 [regulation of satellite cell proliferation] GO:0030210 [heparin biosynthetic process] GO:0030971 [receptor tyrosine kinase binding] GO:0031398 [positive regulation of protein ubiquitination] GO:0034394 [protein localization to cell surface] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043066 [negative regulation of apoptotic process] GO:0043116 [negative regulation of vascular permeability] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048014 [Tie signaling pathway] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050900 [leukocyte migration] GO:0050918 [positive chemotaxis] GO:0051897 [positive regulation of protein kinase B signaling] GO:0070062 [extracellular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0072012 [glomerulus vasculature development] GO:2000352 [negative regulation of endothelial cell apoptotic process]