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UCHL1

GENERAL INFORMATION

Gene name

 UCHL1

Gene description

 Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (hypothalamus, cerebral cortex, hippocampus, pituitary gland, caudate, cerebellum)
FANTOM5:Tissue enhanced (brain, caudate, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in CNS, distal renal tubules, islets of Langerhans and spermatogonia in testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA005993 , CAB002580
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin0200400600800TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (hypothalamus, cerebral cortex, hippocampus, pituitary gland, caudate, cerebellum)
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0100200300400500600RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain, caudate, hippocampus)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina02004006008001,0001,2001,400Tags Per Million

GENE INFORMATION

Gene name

 UCHL1 (HGNC Symbol)

Synonyms

 PARK5, PGP9.5, Uch-L1

Description

 Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]

Chromosome

 4

Cytoband

 p13

Chromosome location (bp)

 41256413 - 41268455

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154277 (version 83.38)

Entrez gene

 7345

UniProt

 P09936 (UniProt - Evidence at protein level)

neXtProt

 NX_P09936

Antibodypedia

 UCHL1 antibodies

PROTEIN BROWSER
UCHL1-001
UCHL1-005
UCHL1-007
UCHL1-009
UCHL1-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UCHL1-001
ENSP00000284440
ENST00000284440
P09936 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase isozyme L1
V9HW74 [Target identity:100%; Query identity:100%]
Ubiquitin carboxyl-terminal hydrolase
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002931 [response to ischemia]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007409 [axonogenesis]
GO:0007412 [axon target recognition]
GO:0007628 [adult walking behavior]
GO:0008242 [omega peptidase activity]
GO:0008283 [cell proliferation]
GO:0016579 [protein deubiquitination]
GO:0016874 [ligase activity]
GO:0019233 [sensory perception of pain]
GO:0019896 [axon transport of mitochondrion]
GO:0030424 [axon]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031694 [alpha-2A adrenergic receptor binding]
GO:0042755 [eating behavior]
GO:0043025 [neuronal cell body]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043209 [myelin sheath]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0044306 [neuron projection terminus]
GO:0048747 [muscle fiber development]
GO:0050905 [neuromuscular process]
GO:0070062 [extracellular exosome]
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 223 aa
24.8 kDa 		No 0
UCHL1-005
ENSP00000422542
ENST00000503431
P09936 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase isozyme L1
V9HW74 [Target identity:100%; Query identity:100%]
Ubiquitin carboxyl-terminal hydrolase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008242 [omega peptidase activity]
GO:0016579 [protein deubiquitination]
GO:0016874 [ligase activity]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031694 [alpha-2A adrenergic receptor binding]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0070062 [extracellular exosome]
Show all
 223 aa
24.8 kDa 		No 0
UCHL1-007
ENSP00000426634
ENST00000514924
D6RF53 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005622 [intracellular]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0016874 [ligase activity]
Show all
 58 aa
6.3 kDa 		No 0
UCHL1-009
ENSP00000426895
ENST00000508768
D6RE83 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0016874 [ligase activity]
Show all
 207 aa
23.2 kDa 		No 0
UCHL1-012
ENSP00000423623
ENST00000512788
D6R956 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0016874 [ligase activity]
Show all
 241 aa
26.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.