Cell atlas - FAM69A - The Human Protein Atlas

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FAM69A

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleus

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	FAM69A
Gene description	Family with sequence similarity 69, member A
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the nucleus.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA015718 , HPA017281
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the nucleus.

Main location

Cytosol (approved)

Additional location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA015718	A-431	Cytosol
	HPA015718	U-2 OS	No staining
	HPA015718	U-251 MG	Cytosol
	HPA017281	A-431	Nucleus
	HPA017281	A-431	Cytosol
	HPA017281	U-251 MG	Cytosol

GENE INFORMATION
Gene name	FAM69A (HGNC Symbol)
Synonyms	FLJ23493
Description	Family with sequence similarity 69, member A (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the FAM69 family of cysteine-rich type II transmembrane proteins. These proteins localize to the endoplasmic reticulum but their specific functions are unknown. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Chromosome	1
Cytoband	p22.1
Chromosome location (bp)	92832737 - 92961522
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154511 (version 83.38)
Entrez gene	388650
UniProt	Q5T7M9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5T7M9
Antibodypedia	FAM69A antibodies

PROTEIN BROWSER

FAM69A-001	FAM69A-201	FAM69A-202	FAM69A-203	FAM69A-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM69A-001 ENSP00000359333 ENST00000370310	Q5T7M9 [Direct mapping] Protein FAM69A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] Show all	428 aa 49 kDa	No	1
FAM69A-201 ENSP00000482478 ENST00000613047	A0A087WZ97 [Direct mapping] Protein FAM69A Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		403 aa 46 kDa	No	0
FAM69A-202 ENSP00000484866 ENST00000613902	A0A087X2C2 [Direct mapping] Protein FAM69A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		383 aa 43.5 kDa	No	0
FAM69A-203 ENSP00000483279 ENST00000615519	Q5T7M9 [Direct mapping] Protein FAM69A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] Show all	162 aa 19 kDa	No	1
FAM69A-204 ENSP00000482718 ENST00000616709	A0A087WZK6 [Direct mapping] Protein FAM69A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	369 aa 42.1 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.