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XPC

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GENERAL INFORMATION

Gene name

 XPC

Gene description

 Xeroderma pigmentosum, complementation group C

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus. In addition localized to the plasma membrane.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (validated)

Additional location

 In addition localized to the Plasma membrane (validated)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Validated based on 3 antibodies.
CAB009932 , HPA035707 , HPA069673
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus. In addition localized to the plasma membrane.

Main location

 Nucleus (validated)

Additional location

 Plasma membrane (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA035707 A-431 Nucleus
Plasma membrane
HPA035707 MCF7 Nucleus
HPA035707 U-2 OS Nucleus
Nucleoli
HPA069673 A549 Nucleus
Vesicles
Plasma membrane
Mitochondria
HPA069673 HeLa Nucleoplasm Spatial
Vesicles
HPA069673 U-2 OS Nucleus
Vesicles
Plasma membrane
CAB009932 A-431 Nucleoplasm
CAB009932 MCF7 Nucleoplasm
CAB009932 U-2 OS Nucleoplasm
Plasma membrane

GENE INFORMATION

Gene name

 XPC (HGNC Symbol)

Synonyms

 RAD4, XPCC

Description

 Xeroderma pigmentosum, complementation group C (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Chromosome

 3

Cytoband

 p25.1

Chromosome location (bp)

 14145147 - 14178783

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154767 (version 83.38)

Entrez gene

 7508

UniProt

 Q01831 (UniProt - Evidence at protein level)

neXtProt

 NX_Q01831

Antibodypedia

 XPC antibodies

PROTEIN BROWSER
XPC-001
XPC-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
XPC-001
ENSP00000285021
ENST00000285021
Q01831 [Direct mapping]
DNA repair protein complementing XP-C cells
X5DRB1 [Target identity:100%; Query identity:100%]
Xeroderma pigmentosum, complementation group C isoform A
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   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000111 [nucleotide-excision repair factor 2 complex]
GO:0000404 [heteroduplex DNA loop binding]
GO:0000405 [bubble DNA binding]
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006298 [mismatch repair]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0010224 [response to UV-B]
GO:0010996 [response to auditory stimulus]
GO:0016925 [protein sumoylation]
GO:0031573 [intra-S DNA damage checkpoint]
GO:0042493 [response to drug]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0070062 [extracellular exosome]
GO:0070911 [global genome nucleotide-excision repair]
GO:0070914 [UV-damage excision repair]
GO:0071942 [XPC complex]
GO:1901990 [regulation of mitotic cell cycle phase transition]
Show all
 940 aa
106 kDa 		No 0
XPC-007
ENSP00000423867
ENST00000511155
E7EUB5 [Direct mapping]
DNA repair protein-complementing XP-C cells
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000111 [nucleotide-excision repair factor 2 complex]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005886 [plasma membrane]
GO:0006298 [mismatch repair]
Show all
 168 aa
18.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.