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Most testicular and thyroid cancers showed moderate cytoplasmic immunoreactivity while weak to moderate positivity was observed in several melanomas, breast, prostate and colorectal cancers. Cancer tissues in general were negative.
Most cancer tissues showed moderate cytoplasmic staining. Several urothelial and a few cases of breast, colorectal, renal and testicular cancers showed strong immunoreactivity.
GENE INFORMATION
Gene name
FGD5 (HGNC Symbol)
Synonyms
FLJ00274, FLJ39957, ZFYVE23
Description
FYVE, RhoGEF and PH domain containing 5 (HGNC Symbol)
H7C0G2 [Direct mapping] FYVE, RhoGEF and PH domain-containing protein 5
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Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity]
B7ZM68 [Direct mapping] FGD5 protein; FYVE, RhoGEF and PH domain-containing protein 5
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Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding]