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Cancer tissues showed weak cytoplasmic staining or were negative. Several cases of breast, prostate and hepatocellular carcinomas displayed moderate cytoplasmic positivity.
Most cancer tissues showed weak to moderate cytoplasmic and membranous immunoreactivity. A few cases of colon cancers were strongly stained. Gliomas and prostate cancers were weakly stained or negative.
GENE INFORMATION
Gene name
CYP2U1 (HGNC Symbol)
Synonyms
SPG49
Description
Cytochrome P450, family 2, subfamily U, polypeptide 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a hydroxylase that metabolizes arachidonic acid, docosahexaenoic acid, and other long chain fatty acids. [provided by RefSeq, Jul 2008]
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)
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GO:0005506 [iron ion binding] GO:0005737 [cytoplasm] GO:0006082 [organic acid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0008395 [steroid hydroxylase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen] GO:0019825 [oxygen binding] GO:0020037 [heme binding] GO:0042738 [exogenous drug catabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process]
