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PROM2

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GENERAL INFORMATION

Gene name

 PROM2

Gene description

 Prominin 2

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the plasma membrane & nucleoplasm. In addition localized to the cell junctions.

RNA cell category

 Cell line enhanced (CAPAN-2, SK-BR-3, A-431, RT4, HaCaT, hTCEpi)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved), Plasma membrane (approved)

Additional location

 In addition localized to the Cell Junctions (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA063728
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CAPAN-2, SK-BR-3, A-431, RT4, HaCaT, hTCEpi)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the plasma membrane & nucleoplasm. In addition localized to the cell junctions.

Main location

 Nucleoplasm (approved), Plasma membrane (approved)

Additional location

 Cell Junctions (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA063728 HaCaT Nucleoplasm
Plasma membrane
HPA063728 MCF7 Nucleoplasm
Plasma membrane
HPA063728 U-2 OS Nucleoplasm
Plasma membrane
Cell Junctions

GENE INFORMATION

Gene name

 PROM2

Synonyms

Description

 Prominin 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the prominin family of pentaspan membrane glycoproteins. The encoded protein localizes to basal epithelial cells and may be involved in the organization of plasma membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Chromosome

 2

Cytoband

 q11.1

Chromosome location (bp)

 95274453 - 95291308

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000155066 (version 83.38)

Entrez gene

 150696

UniProt

 Q8N271 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N271

Antibodypedia

 PROM2 antibodies

PROTEIN BROWSER
PROM2-001
PROM2-002
PROM2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PROM2-001
ENSP00000318520
ENST00000317668
Q8N271 [Direct mapping]
Prominin-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005887 [integral component of plasma membrane]
GO:0005902 [microvillus]
GO:0005929 [cilium]
GO:0009986 [cell surface]
GO:0015485 [cholesterol binding]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0031346 [positive regulation of cell projection organization]
GO:0031410 [cytoplasmic vesicle]
GO:0031528 [microvillus membrane]
GO:0042995 [cell projection]
GO:0043087 [regulation of GTPase activity]
GO:0044393 [microspike]
GO:0045121 [membrane raft]
GO:0048550 [negative regulation of pinocytosis]
GO:0060170 [ciliary membrane]
GO:0070062 [extracellular exosome]
GO:0071914 [prominosome]
GO:2001287 [negative regulation of caveolin-mediated endocytosis]
Show all
 834 aa
91.9 kDa 		Yes 5
PROM2-002
ENSP00000385716
ENST00000403131
Q8N271 [Direct mapping]
Prominin-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005887 [integral component of plasma membrane]
GO:0005902 [microvillus]
GO:0005929 [cilium]
GO:0009986 [cell surface]
GO:0015485 [cholesterol binding]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0031346 [positive regulation of cell projection organization]
GO:0031410 [cytoplasmic vesicle]
GO:0031528 [microvillus membrane]
GO:0042995 [cell projection]
GO:0043087 [regulation of GTPase activity]
GO:0044393 [microspike]
GO:0045121 [membrane raft]
GO:0048550 [negative regulation of pinocytosis]
GO:0060170 [ciliary membrane]
GO:0070062 [extracellular exosome]
GO:0071914 [prominosome]
GO:2001287 [negative regulation of caveolin-mediated endocytosis]
Show all
 834 aa
91.9 kDa 		Yes 5
PROM2-201
ENSP00000318270
ENST00000317620
Q8N271 [Direct mapping]
Prominin-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005902 [microvillus]
GO:0005929 [cilium]
GO:0009986 [cell surface]
GO:0015485 [cholesterol binding]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0031346 [positive regulation of cell projection organization]
GO:0031410 [cytoplasmic vesicle]
GO:0031528 [microvillus membrane]
GO:0042995 [cell projection]
GO:0043087 [regulation of GTPase activity]
GO:0044393 [microspike]
GO:0045121 [membrane raft]
GO:0048550 [negative regulation of pinocytosis]
GO:0060170 [ciliary membrane]
GO:0070062 [extracellular exosome]
GO:0071914 [prominosome]
GO:2001287 [negative regulation of caveolin-mediated endocytosis]
Show all
 834 aa
91.9 kDa 		Yes 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.