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SAMSN1

GENERAL INFORMATION

Gene name

 SAMSN1

Gene description

 SAM domain, SH3 domain and nuclear localization signals 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (bone marrow, appendix)
GTEx:Tissue enhanced (spleen)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissues, most abundant in Leydig cells and immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA010645 , HPA017055
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Appendix

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (bone marrow, appendix)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SAMSN1 (HGNC Symbol)

Synonyms

 HACS1, NASH1, SASH2, SH3D6B, SLy2

Description

 SAM domain, SH3 domain and nuclear localization signals 1 (HGNC Symbol)

Entrez gene summary

 SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains (Claudio et al., 2001 [PubMed 11536050]).[supplied by OMIM, Mar 2008]

Chromosome

 21

Cytoband

 q11.2

Chromosome location (bp)

 14485228 - 14583402

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000155307 (version 83.38)

Entrez gene

 64092

UniProt

 Q9NSI8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NSI8

Antibodypedia

 SAMSN1 antibodies

PROTEIN BROWSER
SAMSN1-001
SAMSN1-002
SAMSN1-003
SAMSN1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SAMSN1-001
ENSP00000285670
ENST00000285670
Q9NSI8 [Direct mapping]
SAM domain-containing protein SAMSN-1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0001784 [phosphotyrosine binding]
GO:0002820 [negative regulation of adaptive immune response]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0044822 [poly(A) RNA binding]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0050869 [negative regulation of B cell activation]
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 441 aa
49.6 kDa 		No 0
SAMSN1-002
ENSP00000383411
ENST00000400566
Q9NSI8 [Direct mapping]
SAM domain-containing protein SAMSN-1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0001784 [phosphotyrosine binding]
GO:0002820 [negative regulation of adaptive immune response]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0044822 [poly(A) RNA binding]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0050869 [negative regulation of B cell activation]
Show all
 373 aa
41.7 kDa 		No 0
SAMSN1-003
ENSP00000383409
ENST00000400564
Q9NSI8 [Direct mapping]
SAM domain-containing protein SAMSN-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0001784 [phosphotyrosine binding]
GO:0002820 [negative regulation of adaptive immune response]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0044822 [poly(A) RNA binding]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0050869 [negative regulation of B cell activation]
Show all
 205 aa
23.5 kDa 		No 0
SAMSN1-201
ENSP00000480850
ENST00000619120
S6FRS6 [Direct mapping]
SAM domain, SH3 domain and nuclear localization signals 1; SAM domain-containing protein SAMSN-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 304 aa
34.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.