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GRIA1

GENERAL INFORMATION

Gene name

 GRIA1

Gene description

 Glutamate receptor, ionotropic, AMPA 1

Protein class

 FDA approved drug targets
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (hippocampus, cerebellum, hypothalamus, cerebral cortex, caudate, lung)
FANTOM5:Tissue enhanced (hippocampus, cerebellum, caudate)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA035202 , CAB001965
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Hippocampus

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (hippocampus, cerebellum, hypothalamus, cerebral cortex, caudate, lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (hippocampus, cerebellum, caudate)

GENE INFORMATION

Gene name

 GRIA1 (HGNC Symbol)

Synonyms

 GluA1, GLUR1, GLURA

Description

 Glutamate receptor, ionotropic, AMPA 1 (HGNC Symbol)

Entrez gene summary

 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q33.2

Chromosome location (bp)

 153489615 - 153813869

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000155511 (version 83.38)

Entrez gene

 2890

UniProt

 P42261 (UniProt - Evidence at protein level)

neXtProt

 NX_P42261

Antibodypedia

 GRIA1 antibodies

PROTEIN BROWSER
GRIA1-001
GRIA1-005
GRIA1-007
GRIA1-010
GRIA1-013
GRIA1-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GRIA1-001
ENSP00000285900
ENST00000285900
P42261 [Direct mapping]
Glutamate receptor 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0004970 [ionotropic glutamate receptor activity]
GO:0004971 [AMPA glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0008066 [glutamate receptor activity]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030425 [dendrite]
GO:0030666 [endocytic vesicle membrane]
GO:0032281 [AMPA glutamate receptor complex]
GO:0032591 [dendritic spine membrane]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044309 [neuron spine]
GO:0045211 [postsynaptic membrane]
GO:0048208 [COPII vesicle coating]
GO:0055037 [recycling endosome]
GO:0061024 [membrane organization]
Show all
 906 aa
101.5 kDa 		Yes 3
GRIA1-005
ENSP00000339343
ENST00000340592
P42261 [Direct mapping]
Glutamate receptor 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0004970 [ionotropic glutamate receptor activity]
GO:0004971 [AMPA glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0008066 [glutamate receptor activity]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030425 [dendrite]
GO:0030666 [endocytic vesicle membrane]
GO:0032281 [AMPA glutamate receptor complex]
GO:0032591 [dendritic spine membrane]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044309 [neuron spine]
GO:0045211 [postsynaptic membrane]
GO:0048208 [COPII vesicle coating]
GO:0055037 [recycling endosome]
GO:0061024 [membrane organization]
Show all
 906 aa
101.5 kDa 		Yes 3
GRIA1-007
ENSP00000428994
ENST00000518783
P42261 [Direct mapping]
Glutamate receptor 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000139 [Golgi membrane]
GO:0004970 [ionotropic glutamate receptor activity]
GO:0004971 [AMPA glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007616 [long-term memory]
GO:0008021 [synaptic vesicle]
GO:0008066 [glutamate receptor activity]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030425 [dendrite]
GO:0030666 [endocytic vesicle membrane]
GO:0031623 [receptor internalization]
GO:0032281 [AMPA glutamate receptor complex]
GO:0032590 [dendrite membrane]
GO:0032591 [dendritic spine membrane]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044308 [axonal spine]
GO:0044309 [neuron spine]
GO:0045211 [postsynaptic membrane]
GO:0048208 [COPII vesicle coating]
GO:0055037 [recycling endosome]
GO:0060292 [long term synaptic depression]
GO:0061024 [membrane organization]
Show all
 916 aa
102.9 kDa 		No 3
GRIA1-010
ENSP00000427864
ENST00000521843
P42261 [Direct mapping]
Glutamate receptor 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000139 [Golgi membrane]
GO:0004970 [ionotropic glutamate receptor activity]
GO:0004971 [AMPA glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0008066 [glutamate receptor activity]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030425 [dendrite]
GO:0030666 [endocytic vesicle membrane]
GO:0032281 [AMPA glutamate receptor complex]
GO:0032591 [dendritic spine membrane]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044309 [neuron spine]
GO:0045211 [postsynaptic membrane]
GO:0048208 [COPII vesicle coating]
GO:0055037 [recycling endosome]
GO:0061024 [membrane organization]
Show all
 837 aa
93.9 kDa 		No 3
GRIA1-013
ENSP00000427920
ENST00000518142
P42261 [Direct mapping]
Glutamate receptor 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000139 [Golgi membrane]
GO:0004970 [ionotropic glutamate receptor activity]
GO:0004971 [AMPA glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0008066 [glutamate receptor activity]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030425 [dendrite]
GO:0030666 [endocytic vesicle membrane]
GO:0032281 [AMPA glutamate receptor complex]
GO:0032591 [dendritic spine membrane]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044309 [neuron spine]
GO:0045211 [postsynaptic membrane]
GO:0048208 [COPII vesicle coating]
GO:0055037 [recycling endosome]
GO:0061024 [membrane organization]
Show all
 826 aa
92.2 kDa 		Yes 3
GRIA1-014
ENSP00000415569
ENST00000448073
P42261 [Direct mapping]
Glutamate receptor 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000139 [Golgi membrane]
GO:0004970 [ionotropic glutamate receptor activity]
GO:0004971 [AMPA glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0008066 [glutamate receptor activity]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030425 [dendrite]
GO:0030666 [endocytic vesicle membrane]
GO:0032281 [AMPA glutamate receptor complex]
GO:0032591 [dendritic spine membrane]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044309 [neuron spine]
GO:0045211 [postsynaptic membrane]
GO:0048208 [COPII vesicle coating]
GO:0055037 [recycling endosome]
GO:0061024 [membrane organization]
Show all
 916 aa
102.9 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.