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Few urothelial and endometrial cancers showed moderate cytoplasmic positivity. Few breast, colorectal, prostatic and cervical cancers showed weak staining. Other cancer tissues were generally negative.
Several colorectal, prostate, stomach cancers along with few endometrial, breast, lung, urothelial cancers and melanomas showed weak to moderate cytoplasmic positivity. Few cases of cervix cancers displayed moderate cytoplasmic and membranous staining. Other cancer tissues were generally negative.
GENE INFORMATION
Gene name
TMEM237 (HGNC Symbol)
Synonyms
ALS2CR4, JBTS14
Description
Transmembrane protein 237 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a tetraspanin protein that is thought to be involved in WNT signaling. Defects in this gene are a cause of Joubert syndrome-14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
