Cell atlas - DEPTOR - The Human Protein Atlas

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DEPTOR

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleoplasm

Human cell
	Mitochondria
	Nucleoplasm

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GENERAL INFORMATION
Gene name	DEPTOR
Gene description	DEP domain containing MTOR-interacting protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria & nucleoplasm.
RNA cell category	Cell line enhanced (RPMI-8226, RPTEC TERT1, Daudi)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Mitochondria (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. CAB020841 , HPA024011
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RPMI-8226, RPTEC TERT1, Daudi) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria & nucleoplasm.

Main location

Nucleoplasm (approved), Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
CAB020841	A-431	Nucleoplasm
CAB020841	A-431	Mitochondria
CAB020841	U-2 OS	Nucleoplasm
CAB020841	U-2 OS	Mitochondria
CAB020841	U-251 MG	Nucleoplasm
CAB020841	U-251 MG	Mitochondria
HPA024011	MCF7	Nucleoplasm
		Cell Junctions
		Mitochondria
HPA024011	U-2 OS	Mitochondria	Intensity

GENE INFORMATION
Gene name	DEPTOR (HGNC Symbol)
Synonyms	DEP.6, DEPDC6, FLJ12428
Description	DEP domain containing MTOR-interacting protein (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	q24.12
Chromosome location (bp)	119873717 - 120050913
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000155792 (version 83.38)
Entrez gene	64798
UniProt	Q8TB45 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TB45
Antibodypedia	DEPTOR antibodies

PROTEIN BROWSER

DEPTOR-001	DEPTOR-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DEPTOR-001 ENSP00000286234 ENST00000286234	Q8TB45 [Direct mapping] DEP domain-containing mTOR-interacting protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0006469 [negative regulation of protein kinase activity] GO:0032007 [negative regulation of TOR signaling] GO:0035556 [intracellular signal transduction] GO:0045792 [negative regulation of cell size] GO:2001236 [regulation of extrinsic apoptotic signaling pathway] Show all	409 aa 46.3 kDa	No	0
DEPTOR-002 ENSP00000430457 ENST00000523492	Q8TB45 [Direct mapping] DEP domain-containing mTOR-interacting protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0006469 [negative regulation of protein kinase activity] GO:0032007 [negative regulation of TOR signaling] GO:0035556 [intracellular signal transduction] GO:0045792 [negative regulation of cell size] GO:2001236 [regulation of extrinsic apoptotic signaling pathway] Show all	308 aa 34 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.