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SLC24A2

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GENERAL INFORMATION

Gene name

 SLC24A2

Gene description

 Solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (U-87 MG, SCLC-21H, K-562)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-87 MG, SCLC-21H, K-562)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 SLC24A2 (HGNC Symbol)

Synonyms

 NCKX2

Description

 Solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Chromosome

 9

Cytoband

 p22.1

Chromosome location (bp)

 19507452 - 19786928

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000155886 (version 83.38)

Entrez gene

 25769

UniProt

 Q9UI40 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UI40

Antibodypedia

 SLC24A2 antibodies

PROTEIN BROWSER
SLC24A2-001
SLC24A2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC24A2-001
ENSP00000344801
ENST00000341998
Q9UI40 [Direct mapping]
Sodium/potassium/calcium exchanger 2
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007601 [visual perception]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0008273 [calcium, potassium:sodium antiporter activity]
GO:0015293 [symporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016151 [nickel cation binding]
GO:0030145 [manganese ion binding]
GO:0030955 [potassium ion binding]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031402 [sodium ion binding]
GO:0034220 [ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0046870 [cadmium ion binding]
GO:0046983 [protein dimerization activity]
GO:0050896 [response to stimulus]
GO:0055085 [transmembrane transport]
GO:0060291 [long-term synaptic potentiation]
GO:0060292 [long term synaptic depression]
GO:0070588 [calcium ion transmembrane transport]
Show all
 661 aa
73.7 kDa 		No >9
SLC24A2-002
ENSP00000286344
ENST00000286344
Q9UI40 [Direct mapping]
Sodium/potassium/calcium exchanger 2
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007601 [visual perception]
GO:0008273 [calcium, potassium:sodium antiporter activity]
GO:0015293 [symporter activity]
GO:0016021 [integral component of membrane]
GO:0030955 [potassium ion binding]
GO:0031402 [sodium ion binding]
GO:0034220 [ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0050896 [response to stimulus]
GO:0055085 [transmembrane transport]
GO:0060291 [long-term synaptic potentiation]
GO:0060292 [long term synaptic depression]
GO:0070588 [calcium ion transmembrane transport]
Show all
 644 aa
71.7 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.