Fields »
ABOUT
HELP
BLOG
SLC24A2

GENERAL INFORMATION

Gene name

 SLC24A2

Gene description

 Solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (caudate, cerebral cortex, hippocampus, hypothalamus, cerebellum)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, cerebral cortex, hippocampus, hypothalamus, cerebellum)

GENE INFORMATION

Gene name

 SLC24A2 (HGNC Symbol)

Synonyms

 NCKX2

Description

 Solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Chromosome

 9

Cytoband

 p22.1

Chromosome location (bp)

 19507452 - 19786928

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000155886 (version 83.38)

Entrez gene

 25769

UniProt

 Q9UI40 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UI40

Antibodypedia

 SLC24A2 antibodies

PROTEIN BROWSER
SLC24A2-001
SLC24A2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC24A2-001
ENSP00000344801
ENST00000341998
Q9UI40 [Direct mapping]
Sodium/potassium/calcium exchanger 2
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007601 [visual perception]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0008273 [calcium, potassium:sodium antiporter activity]
GO:0015293 [symporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016151 [nickel cation binding]
GO:0030145 [manganese ion binding]
GO:0030955 [potassium ion binding]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031402 [sodium ion binding]
GO:0034220 [ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0046870 [cadmium ion binding]
GO:0046983 [protein dimerization activity]
GO:0050896 [response to stimulus]
GO:0055085 [transmembrane transport]
GO:0060291 [long-term synaptic potentiation]
GO:0060292 [long term synaptic depression]
GO:0070588 [calcium ion transmembrane transport]
Show all
 661 aa
73.7 kDa 		No >9
SLC24A2-002
ENSP00000286344
ENST00000286344
Q9UI40 [Direct mapping]
Sodium/potassium/calcium exchanger 2
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007601 [visual perception]
GO:0008273 [calcium, potassium:sodium antiporter activity]
GO:0015293 [symporter activity]
GO:0016021 [integral component of membrane]
GO:0030955 [potassium ion binding]
GO:0031402 [sodium ion binding]
GO:0034220 [ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0050896 [response to stimulus]
GO:0055085 [transmembrane transport]
GO:0060291 [long-term synaptic potentiation]
GO:0060292 [long term synaptic depression]
GO:0070588 [calcium ion transmembrane transport]
Show all
 644 aa
71.7 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.