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VPS37A

GENERAL INFORMATION

Gene name

 VPS37A

Gene description

 Vacuolar protein sorting 37 homolog A (S. cerevisiae)

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA024705 , HPA024781
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 VPS37A (HGNC Symbol)

Synonyms

 FLJ32642, HCRP1, PQBP2, SPG53

Description

 Vacuolar protein sorting 37 homolog A (S. cerevisiae) (HGNC Symbol)

Entrez gene summary

 This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

Chromosome

 8

Cytoband

 p22

Chromosome location (bp)

 17246571 - 17302427

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000155975 (version 83.38)

Entrez gene

 137492

UniProt

 Q8NEZ2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NEZ2

Antibodypedia

 VPS37A antibodies

PROTEIN BROWSER
VPS37A-001
VPS37A-003
VPS37A-005
VPS37A-006
VPS37A-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VPS37A-001
ENSP00000318629
ENST00000324849
Q8NEZ2 [Direct mapping]
Vacuolar protein sorting-associated protein 37A
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000813 [ESCRT I complex]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0010008 [endosome membrane]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016197 [endosomal transport]
GO:0019058 [viral life cycle]
GO:0019068 [virion assembly]
GO:0019082 [viral protein processing]
GO:0031902 [late endosome membrane]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0061024 [membrane organization]
GO:0075733 [intracellular transport of virus]
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 397 aa
44.3 kDa 		No 0
VPS37A-003
ENSP00000429680
ENST00000521829
Q8NEZ2 [Direct mapping]
Vacuolar protein sorting-associated protein 37A
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000813 [ESCRT I complex]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0010008 [endosome membrane]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016197 [endosomal transport]
GO:0019058 [viral life cycle]
GO:0019068 [virion assembly]
GO:0019082 [viral protein processing]
GO:0031902 [late endosome membrane]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0061024 [membrane organization]
GO:0075733 [intracellular transport of virus]
Show all
 372 aa
41.5 kDa 		No 0
VPS37A-005
ENSP00000430456
ENST00000518038
E5RJX6 [Direct mapping]
Vacuolar protein sorting-associated protein 37A
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 116 aa
12.8 kDa 		No 0
VPS37A-006
ENSP00000430933
ENST00000521005
E5RHB8 [Direct mapping]
Vacuolar protein sorting-associated protein 37A
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 76 aa
8.1 kDa 		No 0
VPS37A-008
ENSP00000429858
ENST00000521976
H0YBN0 [Direct mapping]
Vacuolar protein sorting-associated protein 37A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 170 aa
19.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.