Expression of KIF5A in cancer - Summary

CANCER ATLAS

Gene description

Kinesin family member 5A

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA004469	CAB015157

GENE INFORMATION
Gene name	KIF5A (HGNC Symbol)
Synonyms	D12S1889, MY050, NKHC, SPG10
Description	Kinesin family member 5A (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q13.3
Chromosome location (bp)	57549998 - 57586632
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000155980 (version 83.38)
Entrez gene	3798
UniProt	Q12840 (UniProt - Evidence at protein level)
neXtProt	NX_Q12840
Antibodypedia	KIF5A antibodies

PROTEIN BROWSER

KIF5A-001	KIF5A-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KIF5A-001 ENSP00000408979 ENST00000455537	Q12840 [Direct mapping] Kinesin heavy chain isoform 5A Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003774 [motor activity] GO:0003777 [microtubule motor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0005871 [kinesin complex] GO:0005874 [microtubule] GO:0007018 [microtubule-based movement] GO:0007264 [small GTPase mediated signal transduction] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008017 [microtubule binding] GO:0008104 [protein localization] GO:0008152 [metabolic process] GO:0008574 [ATP-dependent microtubule motor activity, plus-end-directed] GO:0016020 [membrane] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0030705 [cytoskeleton-dependent intracellular transport] GO:0048471 [perinuclear region of cytoplasm] Show all	1032 aa 117.4 kDa	No	0
KIF5A-002 ENSP00000286452 ENST00000286452	J3KNA1 [Direct mapping] Kinesin-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003777 [microtubule motor activity] GO:0005524 [ATP binding] GO:0005871 [kinesin complex] GO:0005874 [microtubule] GO:0007018 [microtubule-based movement] GO:0007411 [axon guidance] GO:0008017 [microtubule binding] GO:0008104 [protein localization] GO:0008152 [metabolic process] GO:0008574 [ATP-dependent microtubule motor activity, plus-end-directed] GO:0030705 [cytoskeleton-dependent intracellular transport] Show all	943 aa 107.3 kDa	No	0