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KIF5A

GENERAL INFORMATION

Gene name

 KIF5A

Gene description

 Kinesin family member 5A

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Tissue enhanced (cerebral cortex, hippocampus)
FANTOM5:Group enriched (brain, hippocampus, caudate, cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression in essentially all cells, most abundant in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA004469 , CAB015157
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, hippocampus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, hippocampus, caudate, cerebellum)

GENE INFORMATION

Gene name

 KIF5A (HGNC Symbol)

Synonyms

 D12S1889, MY050, NKHC, SPG10

Description

 Kinesin family member 5A (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.3

Chromosome location (bp)

 57549998 - 57586632

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000155980 (version 83.38)

Entrez gene

 3798

UniProt

 Q12840 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12840

Antibodypedia

 KIF5A antibodies

PROTEIN BROWSER
KIF5A-001
KIF5A-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KIF5A-001
ENSP00000408979
ENST00000455537
Q12840 [Direct mapping]
Kinesin heavy chain isoform 5A
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003774 [motor activity]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0008104 [protein localization]
GO:0008152 [metabolic process]
GO:0008574 [ATP-dependent microtubule motor activity, plus-end-directed]
GO:0016020 [membrane]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030705 [cytoskeleton-dependent intracellular transport]
GO:0048471 [perinuclear region of cytoplasm]
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 1032 aa
117.4 kDa 		No 0
KIF5A-002
ENSP00000286452
ENST00000286452
J3KNA1 [Direct mapping]
Kinesin-like protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0007411 [axon guidance]
GO:0008017 [microtubule binding]
GO:0008104 [protein localization]
GO:0008152 [metabolic process]
GO:0008574 [ATP-dependent microtubule motor activity, plus-end-directed]
GO:0030705 [cytoskeleton-dependent intracellular transport]
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 943 aa
107.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.