Expression of MCU in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Mitochondrial calcium uniporter

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA016480

GENE INFORMATION
Gene name	MCU (HGNC Symbol)
Synonyms	C10orf42, CCDC109A, FLJ46135
Description	Mitochondrial calcium uniporter (HGNC Symbol)
Entrez gene summary	This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Chromosome	10
Cytoband	q22.1
Chromosome location (bp)	72692131 - 72887694
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156026 (version 83.38)
Entrez gene	90550
UniProt	Q8NE86 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NE86
Antibodypedia	MCU antibodies

PROTEIN BROWSER

MCU-001	MCU-002	MCU-008	MCU-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MCU-001 ENSP00000349680 ENST00000357157	Q8NE86 [Direct mapping] Calcium uniporter protein, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006851 [mitochondrial calcium ion transport] GO:0015292 [uniporter activity] GO:0019722 [calcium-mediated signaling] GO:0031305 [integral component of mitochondrial inner membrane] GO:0032024 [positive regulation of insulin secretion] GO:0034704 [calcium channel complex] GO:0035786 [protein complex oligomerization] GO:0036444 [calcium ion transmembrane import into mitochondrion] GO:0042593 [glucose homeostasis] GO:0051561 [positive regulation of mitochondrial calcium ion concentration] GO:1990246 [uniplex complex] Show all	330 aa 37 kDa	Yes	2
MCU-002 ENSP00000362144 ENST00000373053	Q8NE86 [Direct mapping] Calcium uniporter protein, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006851 [mitochondrial calcium ion transport] GO:0015292 [uniporter activity] GO:0019722 [calcium-mediated signaling] GO:0031305 [integral component of mitochondrial inner membrane] GO:0032024 [positive regulation of insulin secretion] GO:0034704 [calcium channel complex] GO:0035786 [protein complex oligomerization] GO:0036444 [calcium ion transmembrane import into mitochondrion] GO:0042593 [glucose homeostasis] GO:0042802 [identical protein binding] GO:0051560 [mitochondrial calcium ion homeostasis] GO:0051561 [positive regulation of mitochondrial calcium ion concentration] GO:1990246 [uniplex complex] Show all	351 aa 39.9 kDa	Yes	2
MCU-008 ENSP00000475141 ENST00000604152	S4R468 [Direct mapping] Calcium uniporter protein, mitochondrial Show all	Phobius predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	167 aa 19 kDa	No	0
MCU-201 ENSP00000440913 ENST00000536019	Q8NE86 [Direct mapping] Calcium uniporter protein, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006851 [mitochondrial calcium ion transport] GO:0015292 [uniporter activity] GO:0019722 [calcium-mediated signaling] GO:0031305 [integral component of mitochondrial inner membrane] GO:0032024 [positive regulation of insulin secretion] GO:0034704 [calcium channel complex] GO:0035786 [protein complex oligomerization] GO:0036444 [calcium ion transmembrane import into mitochondrion] GO:0042593 [glucose homeostasis] GO:0051561 [positive regulation of mitochondrial calcium ion concentration] GO:1990246 [uniplex complex] Show all	302 aa 35.2 kDa	No	2