Expression of N6AMT1 in cancer - Summary

CANCER ATLAS

Gene description

N-6 adenine-specific DNA methyltransferase 1 (putative)

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Endometrial cancer

STAINING SUMMARY

CAB034133	CAB034135

GENE INFORMATION
Gene name	N6AMT1 (HGNC Symbol)
Synonyms	C21orf127, HEMK2, MTQ2, N6AMT, PRED28
Description	N-6 adenine-specific DNA methyltransferase 1 (putative) (HGNC Symbol)
Entrez gene summary	This gene encodes an N(6)-adenine-specific DNA methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. Alternative splicing pf this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jul 2014]
Chromosome	21
Cytoband	q21.3
Chromosome location (bp)	28872191 - 28885371
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156239 (version 83.38)
Entrez gene	29104
UniProt	Q9Y5N5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5N5
Antibodypedia	N6AMT1 antibodies

PROTEIN BROWSER

N6AMT1-001	N6AMT1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
N6AMT1-001 ENSP00000303584 ENST00000303775	B2RA97 [Direct mapping] HemK methyltransferase family member 2; HemK methyltransferase family member 2, isoform CRA_a; cDNA, FLJ94785, Homo sapiens putative N6-DNA-methyltransferase (N6AMT1), mRNA Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0006479 [protein methylation] GO:0008168 [methyltransferase activity] GO:0008276 [protein methyltransferase activity] GO:0032259 [methylation] Show all	214 aa 23 kDa	No	0
N6AMT1-002 ENSP00000286764 ENST00000351429	Q9Y5N5 [Direct mapping] HemK methyltransferase family member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0006479 [protein methylation] GO:0008168 [methyltransferase activity] GO:0008276 [protein methyltransferase activity] GO:0030307 [positive regulation of cell growth] GO:0043234 [protein complex] Show all	186 aa 19.8 kDa	No	0