Cell atlas - N6AMT1 - The Human Protein Atlas

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N6AMT1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Nucleoplasm

Human cell
	Centrosome
	Nucleoplasm

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GENERAL INFORMATION
Gene name	N6AMT1
Gene description	N-6 adenine-specific DNA methyltransferase 1 (putative)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the centrosome. In addition localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Centrosome (approved)
Additional location	In addition localized to the Nucleoplasm (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by correlation analysis

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA059242
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the centrosome. In addition localized to the nucleoplasm.

Main location

Centrosome (approved)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA059242	A-431	Nucleoplasm	Intensity
	HPA059242	A-431	Centrosome
	HPA059242	HEK 293	Centrosome
	HPA059242	U-2 OS	Nucleoplasm	Intensity	Intensity
	HPA059242	U-2 OS	Centrosome

CELL CYCLE
Summary	Expression has cell cycle dependency according to correlation analysis
Intensity variation	Nucleoplasm
HPA059242

GENE INFORMATION
Gene name	N6AMT1 (HGNC Symbol)
Synonyms	C21orf127, HEMK2, MTQ2, N6AMT, PRED28
Description	N-6 adenine-specific DNA methyltransferase 1 (putative) (HGNC Symbol)
Entrez gene summary	This gene encodes an N(6)-adenine-specific DNA methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. Alternative splicing pf this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jul 2014]
Chromosome	21
Cytoband	q21.3
Chromosome location (bp)	28872191 - 28885371
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156239 (version 83.38)
Entrez gene	29104
UniProt	Q9Y5N5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5N5
Antibodypedia	N6AMT1 antibodies

PROTEIN BROWSER

N6AMT1-001	N6AMT1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
N6AMT1-001 ENSP00000303584 ENST00000303775	B2RA97 [Direct mapping] HemK methyltransferase family member 2; HemK methyltransferase family member 2, isoform CRA_a; cDNA, FLJ94785, Homo sapiens putative N6-DNA-methyltransferase (N6AMT1), mRNA Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0006479 [protein methylation] GO:0008168 [methyltransferase activity] GO:0008276 [protein methyltransferase activity] GO:0032259 [methylation] Show all	214 aa 23 kDa	No	0
N6AMT1-002 ENSP00000286764 ENST00000351429	Q9Y5N5 [Direct mapping] HemK methyltransferase family member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0006479 [protein methylation] GO:0008168 [methyltransferase activity] GO:0008276 [protein methyltransferase activity] GO:0030307 [positive regulation of cell growth] GO:0043234 [protein complex] Show all	186 aa 19.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.