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Few cases of colorectal cancers displayed moderate to strong cytoplasmic staining with additional membranous and nuclear positivity in urothelial cancers. Occasional cases of pancreatic, endometrial, cervical and ovarian cancers were moderately stained. Remaining cancer tissues were weakly stained or negative.
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]