Cell atlas - FUT6 - The Human Protein Atlas

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FUT6

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	FUT6
Gene description	Fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Group enriched (Hep G2, RPMI-8226)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA043707
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (Hep G2, RPMI-8226) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA043707	A-431	No staining
	HPA043707	Hep G2	Golgi apparatus	Intensity
	HPA043707	U-2 OS	No staining

GENE INFORMATION
Gene name	FUT6 (HGNC Symbol)
Synonyms	FCT3A, FLJ40754, FT1A, FucT-VI
Description	Fucosyltransferase 6 (alpha (1,3) fucosyltransferase) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	5830610 - 5839731
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156413 (version 83.38)
Entrez gene	2528
UniProt	P51993 (UniProt - Evidence at protein level)
neXtProt	NX_P51993
Antibodypedia	FUT6 antibodies

PROTEIN BROWSER

FUT6-001	FUT6-002	FUT6-003	FUT6-004	FUT6-005	FUT6-006	FUT6-007	FUT6-008	FUT6-011	FUT6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FUT6-001 ENSP00000286955 ENST00000286955	P51993 [Direct mapping] Alpha-(1,3)-fucosyltransferase 6 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0006486 [protein glycosylation] GO:0008417 [fucosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017060 [3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity] GO:0032580 [Golgi cisterna membrane] GO:0036065 [fucosylation] GO:0042355 [L-fucose catabolic process] GO:0046920 [alpha-(1->3)-fucosyltransferase activity] GO:0070062 [extracellular exosome] Show all	359 aa 41.9 kDa	No	1
FUT6-002 ENSP00000432954 ENST00000527106	P51993 [Direct mapping] Alpha-(1,3)-fucosyltransferase 6 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005794 [Golgi apparatus] GO:0006486 [protein glycosylation] GO:0008417 [fucosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017060 [3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity] GO:0032580 [Golgi cisterna membrane] GO:0036065 [fucosylation] GO:0042355 [L-fucose catabolic process] GO:0046920 [alpha-(1->3)-fucosyltransferase activity] GO:0070062 [extracellular exosome] Show all	359 aa 41.9 kDa	No	1
FUT6-003 ENSP00000431708 ENST00000524754	P51993 [Direct mapping] Alpha-(1,3)-fucosyltransferase 6 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005794 [Golgi apparatus] GO:0006486 [protein glycosylation] GO:0008417 [fucosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017060 [3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity] GO:0032580 [Golgi cisterna membrane] GO:0036065 [fucosylation] GO:0042355 [L-fucose catabolic process] GO:0046920 [alpha-(1->3)-fucosyltransferase activity] GO:0070062 [extracellular exosome] Show all	359 aa 41.9 kDa	No	1
FUT6-004 ENSP00000436547 ENST00000529165	E9PI36 [Direct mapping] Alpha-(1,3)-fucosyltransferase 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0006486 [protein glycosylation] GO:0008417 [fucosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0036065 [fucosylation] Show all	137 aa 15.7 kDa	No	1
FUT6-005 ENSP00000436413 ENST00000531199	E9PP56 [Direct mapping] Alpha-(1,3)-fucosyltransferase 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0006486 [protein glycosylation] GO:0008417 [fucosyltransferase activity] GO:0016021 [integral component of membrane] GO:0036065 [fucosylation] Show all	66 aa 7.4 kDa	No	1
FUT6-006 ENSP00000433811 ENST00000528505	E9PJB4 [Direct mapping] Alpha-(1,3)-fucosyltransferase 6 Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0006486 [protein glycosylation] GO:0008417 [fucosyltransferase activity] GO:0016020 [membrane] GO:0036065 [fucosylation] Show all	30 aa 3.5 kDa	No	0
FUT6-007 ENSP00000431880 ENST00000532464	E9PJ18 [Direct mapping] Alpha-(1,3)-fucosyltransferase 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0006486 [protein glycosylation] GO:0008417 [fucosyltransferase activity] GO:0016021 [integral component of membrane] GO:0036065 [fucosylation] Show all	45 aa 5.2 kDa	No	1
FUT6-008 ENSP00000432161 ENST00000531085	E9PS22 [Direct mapping] Alpha-(1,3)-fucosyltransferase 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0006486 [protein glycosylation] GO:0008417 [fucosyltransferase activity] GO:0016021 [integral component of membrane] GO:0036065 [fucosylation] Show all	69 aa 7.9 kDa	No	1
FUT6-011 ENSP00000466016 ENST00000592563	P51993 [Direct mapping] Alpha-(1,3)-fucosyltransferase 6 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005794 [Golgi apparatus] GO:0006486 [protein glycosylation] GO:0008417 [fucosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017060 [3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity] GO:0032580 [Golgi cisterna membrane] GO:0036065 [fucosylation] GO:0042355 [L-fucose catabolic process] GO:0046920 [alpha-(1->3)-fucosyltransferase activity] GO:0070062 [extracellular exosome] Show all	364 aa 42.2 kDa	No	1
FUT6-201 ENSP00000313398 ENST00000318336	P51993 [Direct mapping] Alpha-(1,3)-fucosyltransferase 6 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0006486 [protein glycosylation] GO:0008417 [fucosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017060 [3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity] GO:0032580 [Golgi cisterna membrane] GO:0036065 [fucosylation] GO:0042355 [L-fucose catabolic process] GO:0046920 [alpha-(1->3)-fucosyltransferase activity] GO:0070062 [extracellular exosome] Show all	359 aa 41.9 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.