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HK1

GENERAL INFORMATION

Gene name

 HK1

Gene description

 Hexokinase 1

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression with a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 4 antibodies.
HPA007043 , HPA007044 , HPA011956 , CAB010052
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 HK1

Synonyms

Description

 Hexokinase 1 (HGNC Symbol)

Entrez gene summary

 Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. [provided by RefSeq, Apr 2009]

Chromosome

 10

Cytoband

 q22.1

Chromosome location (bp)

 69269984 - 69401882

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156515 (version 83.38)

Entrez gene

 3098

UniProt

 P19367 (UniProt - Evidence at protein level)

neXtProt

 NX_P19367

Antibodypedia

 HK1 antibodies

PROTEIN BROWSER
HK1-001
HK1-003
HK1-004
HK1-016
HK1-201
HK1-202
HK1-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HK1-001
ENSP00000352398
ENST00000359426
P19367 [Direct mapping]
Hexokinase-1
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0004340 [glucokinase activity]
GO:0004396 [hexokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0008645 [hexose transport]
GO:0008865 [fructokinase activity]
GO:0015758 [glucose transport]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0019158 [mannokinase activity]
GO:0044281 [small molecule metabolic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0051156 [glucose 6-phosphate metabolic process]
GO:0055085 [transmembrane transport]
GO:0061621 [canonical glycolysis]
GO:0072655 [establishment of protein localization to mitochondrion]
GO:0072656 [maintenance of protein location in mitochondrion]
GO:1903599 [positive regulation of mitophagy]
Show all
 917 aa
102.5 kDa 		No 0
HK1-003
ENSP00000409761
ENST00000450646
B1AR61 [Direct mapping]
Hexokinase-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0004340 [glucokinase activity]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006096 [glycolytic process]
GO:0008865 [fructokinase activity]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0019158 [mannokinase activity]
GO:0046835 [carbohydrate phosphorylation]
GO:0051156 [glucose 6-phosphate metabolic process]
Show all
 139 aa
15.7 kDa 		No 0
HK1-004
ENSP00000398316
ENST00000421088
B1AR62 [Direct mapping]
Hexokinase-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0004340 [glucokinase activity]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006096 [glycolytic process]
GO:0008865 [fructokinase activity]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0019158 [mannokinase activity]
GO:0046835 [carbohydrate phosphorylation]
GO:0051156 [glucose 6-phosphate metabolic process]
Show all
 114 aa
13 kDa 		No 0
HK1-016
ENSP00000415949
ENST00000436817
B1AR63 [Direct mapping]
Hexokinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0004340 [glucokinase activity]
GO:0004396 [hexokinase activity]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006096 [glycolytic process]
GO:0008865 [fructokinase activity]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0019158 [mannokinase activity]
GO:0046835 [carbohydrate phosphorylation]
GO:0051156 [glucose 6-phosphate metabolic process]
Show all
 291 aa
32.7 kDa 		No 0
HK1-201
ENSP00000298649
ENST00000298649
P19367 [Direct mapping]
Hexokinase-1
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0004340 [glucokinase activity]
GO:0004396 [hexokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0008645 [hexose transport]
GO:0008865 [fructokinase activity]
GO:0015758 [glucose transport]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0019158 [mannokinase activity]
GO:0044281 [small molecule metabolic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0051156 [glucose 6-phosphate metabolic process]
GO:0055085 [transmembrane transport]
GO:0061621 [canonical glycolysis]
GO:0072655 [establishment of protein localization to mitochondrion]
GO:0072656 [maintenance of protein location in mitochondrion]
GO:1903599 [positive regulation of mitophagy]
Show all
 916 aa
102.2 kDa 		No 0
HK1-202
ENSP00000353433
ENST00000360289
P19367 [Direct mapping]
Hexokinase-1
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0004340 [glucokinase activity]
GO:0004396 [hexokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0008645 [hexose transport]
GO:0008865 [fructokinase activity]
GO:0015758 [glucose transport]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0019158 [mannokinase activity]
GO:0044281 [small molecule metabolic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0051156 [glucose 6-phosphate metabolic process]
GO:0055085 [transmembrane transport]
GO:0061621 [canonical glycolysis]
GO:0072655 [establishment of protein localization to mitochondrion]
GO:0072656 [maintenance of protein location in mitochondrion]
GO:1903599 [positive regulation of mitophagy]
Show all
 905 aa
101.1 kDa 		No 0
HK1-203
ENSP00000402103
ENST00000448642
P19367 [Direct mapping]
Hexokinase-1
A0A024QZK7 [Target identity:100%; Query identity:100%]
Hexokinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0004340 [glucokinase activity]
GO:0004396 [hexokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005929 [cilium]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0008645 [hexose transport]
GO:0008865 [fructokinase activity]
GO:0015758 [glucose transport]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0019158 [mannokinase activity]
GO:0044281 [small molecule metabolic process]
GO:0045121 [membrane raft]
GO:0046835 [carbohydrate phosphorylation]
GO:0051156 [glucose 6-phosphate metabolic process]
GO:0055085 [transmembrane transport]
GO:0061621 [canonical glycolysis]
GO:0072655 [establishment of protein localization to mitochondrion]
GO:0072656 [maintenance of protein location in mitochondrion]
GO:0097228 [sperm principal piece]
GO:1903599 [positive regulation of mitophagy]
Show all
 921 aa
102.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.