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NPTN

CANCER ATLAS

Gene description

 Neuroplastin

Protein class

 Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA051497
HPA072453

GENE INFORMATION

Gene name

 NPTN (HGNC Symbol)

Synonyms

 GP55, GP65, np55, np65, SDFR1, SDR1

Description

 Neuroplastin (HGNC Symbol)

Entrez gene summary

 This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2009]

Chromosome

 15

Cytoband

 q24.1

Chromosome location (bp)

 73560014 - 73634134

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156642 (version 83.38)

Entrez gene

 27020

UniProt

 Q9Y639 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y639

Antibodypedia

 NPTN antibodies

PROTEIN BROWSER
NPTN-001
NPTN-002
NPTN-003
NPTN-004
NPTN-005
NPTN-008
NPTN-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NPTN-001
ENSP00000290401
ENST00000345330
Q9Y639 [Direct mapping]
Neuroplastin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005105 [type 1 fibroblast growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008542 [visual learning]
GO:0009986 [cell surface]
GO:0010976 [positive regulation of neuron projection development]
GO:0014069 [postsynaptic density]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030425 [dendrite]
GO:0042734 [presynaptic membrane]
GO:0044325 [ion channel binding]
GO:0045743 [positive regulation of fibroblast growth factor receptor signaling pathway]
GO:0048170 [positive regulation of long-term neuronal synaptic plasticity]
GO:0050839 [cell adhesion molecule binding]
GO:0060077 [inhibitory synapse]
GO:0060291 [long-term synaptic potentiation]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0097060 [synaptic membrane]
GO:1900273 [positive regulation of long-term synaptic potentiation]
GO:1903829 [positive regulation of cellular protein localization]
Show all
 398 aa
44.4 kDa 		Yes 1
NPTN-002
ENSP00000342958
ENST00000351217
Q9Y639 [Direct mapping]
Neuroplastin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005105 [type 1 fibroblast growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0009986 [cell surface]
GO:0010976 [positive regulation of neuron projection development]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0042734 [presynaptic membrane]
GO:0045743 [positive regulation of fibroblast growth factor receptor signaling pathway]
GO:0048170 [positive regulation of long-term neuronal synaptic plasticity]
GO:0050839 [cell adhesion molecule binding]
GO:0060291 [long-term synaptic potentiation]
Show all
 282 aa
31.3 kDa 		Yes 1
NPTN-003
ENSP00000457470
ENST00000565325
H3BU51 [Direct mapping]
Neuroplastin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
 184 aa
20.1 kDa 		Yes 1
NPTN-004
ENSP00000456033
ENST00000565282
Q9UFM8 [Direct mapping]
Neuroplastin; Putative uncharacterized protein DKFZp566H1924
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 308 aa
34.8 kDa 		No 0
NPTN-005
ENSP00000457028
ENST00000563691
Q9Y639 [Direct mapping]
Neuroplastin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005105 [type 1 fibroblast growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0009986 [cell surface]
GO:0010976 [positive regulation of neuron projection development]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0042734 [presynaptic membrane]
GO:0045743 [positive regulation of fibroblast growth factor receptor signaling pathway]
GO:0048170 [positive regulation of long-term neuronal synaptic plasticity]
GO:0050839 [cell adhesion molecule binding]
GO:0060291 [long-term synaptic potentiation]
Show all
 394 aa
43.9 kDa 		Yes 1
NPTN-008
ENSP00000456349
ENST00000562924
Q9Y639 [Direct mapping]
Neuroplastin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005105 [type 1 fibroblast growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0009986 [cell surface]
GO:0010976 [positive regulation of neuron projection development]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0042734 [presynaptic membrane]
GO:0045743 [positive regulation of fibroblast growth factor receptor signaling pathway]
GO:0048170 [positive regulation of long-term neuronal synaptic plasticity]
GO:0050839 [cell adhesion molecule binding]
GO:0060291 [long-term synaptic potentiation]
Show all
 278 aa
30.8 kDa 		Yes 1
NPTN-011
ENSP00000455671
ENST00000567198
H3BQ94 [Direct mapping]
Neuroplastin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 152 aa
17.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.