Tissue expression of NPTN - Summary - The Human Protein Atlas

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NPTN

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	NPTN
Gene description	Neuroplastin
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membrane expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA051497 , HPA072453
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	NPTN (HGNC Symbol)
Synonyms	GP55, GP65, np55, np65, SDFR1, SDR1
Description	Neuroplastin (HGNC Symbol)
Entrez gene summary	This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2009]
Chromosome	15
Cytoband	q24.1
Chromosome location (bp)	73560014 - 73634134
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156642 (version 83.38)
Entrez gene	27020
UniProt	Q9Y639 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y639
Antibodypedia	NPTN antibodies

PROTEIN BROWSER

NPTN-001	NPTN-002	NPTN-003	NPTN-004	NPTN-005	NPTN-008	NPTN-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPTN-001 ENSP00000290401 ENST00000345330	Q9Y639 [Direct mapping] Neuroplastin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005104 [fibroblast growth factor receptor binding] GO:0005105 [type 1 fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008542 [visual learning] GO:0009986 [cell surface] GO:0010976 [positive regulation of neuron projection development] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030425 [dendrite] GO:0042734 [presynaptic membrane] GO:0044325 [ion channel binding] GO:0045743 [positive regulation of fibroblast growth factor receptor signaling pathway] GO:0048170 [positive regulation of long-term neuronal synaptic plasticity] GO:0050839 [cell adhesion molecule binding] GO:0060077 [inhibitory synapse] GO:0060291 [long-term synaptic potentiation] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0097060 [synaptic membrane] GO:1900273 [positive regulation of long-term synaptic potentiation] GO:1903829 [positive regulation of cellular protein localization] Show all	398 aa 44.4 kDa	Yes	1
NPTN-002 ENSP00000342958 ENST00000351217	Q9Y639 [Direct mapping] Neuroplastin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005105 [type 1 fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0009986 [cell surface] GO:0010976 [positive regulation of neuron projection development] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0042734 [presynaptic membrane] GO:0045743 [positive regulation of fibroblast growth factor receptor signaling pathway] GO:0048170 [positive regulation of long-term neuronal synaptic plasticity] GO:0050839 [cell adhesion molecule binding] GO:0060291 [long-term synaptic potentiation] Show all	282 aa 31.3 kDa	Yes	1
NPTN-003 ENSP00000457470 ENST00000565325	H3BU51 [Direct mapping] Neuroplastin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	184 aa 20.1 kDa	Yes	1
NPTN-004 ENSP00000456033 ENST00000565282	Q9UFM8 [Direct mapping] Neuroplastin; Putative uncharacterized protein DKFZp566H1924 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	308 aa 34.8 kDa	No	0
NPTN-005 ENSP00000457028 ENST00000563691	Q9Y639 [Direct mapping] Neuroplastin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005105 [type 1 fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0009986 [cell surface] GO:0010976 [positive regulation of neuron projection development] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0042734 [presynaptic membrane] GO:0045743 [positive regulation of fibroblast growth factor receptor signaling pathway] GO:0048170 [positive regulation of long-term neuronal synaptic plasticity] GO:0050839 [cell adhesion molecule binding] GO:0060291 [long-term synaptic potentiation] Show all	394 aa 43.9 kDa	Yes	1
NPTN-008 ENSP00000456349 ENST00000562924	Q9Y639 [Direct mapping] Neuroplastin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005105 [type 1 fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0009986 [cell surface] GO:0010976 [positive regulation of neuron projection development] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0042734 [presynaptic membrane] GO:0045743 [positive regulation of fibroblast growth factor receptor signaling pathway] GO:0048170 [positive regulation of long-term neuronal synaptic plasticity] GO:0050839 [cell adhesion molecule binding] GO:0060291 [long-term synaptic potentiation] Show all	278 aa 30.8 kDa	Yes	1
NPTN-011 ENSP00000455671 ENST00000567198	H3BQ94 [Direct mapping] Neuroplastin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	152 aa 17.2 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.